31733-79-6

Upstream product

• 175658-16-9 α-(phenylthio)-N-methyl-N-phenylacetamide 
• 98-95-3 nitrobenzene 
• 100-61-8 N-methylaniline 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 104-03-0 4-nitrobenzeneacetic acid 

Downstream Products

• 31733-80-9 4-amino-N-methyl-N-phenyl-benzeneacetamide 

Relevant academic research and scientific papers

Hypervalent iodine(III)-mediated oxidative dearomatizing cyclization of arylamines

An oxidative dearomatizing cyclization of arylamines promoted by iodobenzene bis(trifluoroacetate) [PhI(CF3CO2) 2] has been explored, leading to a novel synthetic approach to functionalized spirocyclic building blocks containing the structurally unique dieniminium moiety. This unprecedented methodology, featuring oxidative dearomatization and carbon-carbon bond-forming cyclization, to some extent, not only expands the synthetic potential of hypervalent iodine chemistry, but also enriches the oxidation chemistry of arylamines.

Vicarious nucleophilic substitution of hydrogen proceeding via heterocyclic ring opening

Carbanions of five-membered S-heterocycles react with nitroarenes via the ring-opening VNS reaction or oxidative nucleophilic substitution of hydrogen. The reaction course is affected by rigidity of the ring.