317334-84-2

Upstream product

• 321923-87-9 (3-bromo-4-fluorophenyl)phenylmethanol 
• 109-63-7 trifluoroborane diethyl ether 
• 77771-02-9 3-bromo-4-fluorobenzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 77771-03-0 3-bromo-4-fluoro-benzyl alcohol 
• 71-43-2 benzene 

Downstream Products

• 321923-88-0 5-benzyl-2-fluorobenzonitrile 
• 13294-41-2 (3-bromo-4-fluorophenyl)(phenyl)methanone 
• 251966-63-9 1-(5-benzyl-2-isopropoxyphenyl)ethanone 
• 1025800-83-2 1-(5-benzyl-2-ethoxy-phenyl)-ethanone 
• 251966-64-0 5-benzyl-2-isopropoxybenzonitrile 
• 1026672-63-8 5-benzyl-2-ethoxy-benzonitrile 

Relevant academic research and scientific papers

Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 C-H oxidation

Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on 18O-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases.

1-(Aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof

Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

HIV integrase inhibitors

Certain six-membered aromatic and heteroaromatic-dioxobutyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment