317334-99-9

Upstream product

• 556-96-7 5-bromo-1,3-xylene 
• 288-13-1 NH-pyrazole 
• 51760-23-7 1-bromo-3,5-bis(bromomethyl)benzene 

Downstream Products

• 317335-01-6 ethyl 3,5-bis-pyrazol-1-ylmethylbenzoate 
• 317335-02-7 3,5-bis-pyrazol-1-ylmethylbenzoic acid 
• 317335-03-8 3,5-bis-pyrazol-1-ylmethylbenzoyl chloride 
• 317333-78-1 1-[3,5-bis(1H-pyrazol-1-ylmethyl)phenyl]-3-(1H-imidazol-2-yl)propane-1,3-dione 
• 317333-76-9 1-(3,5-bis-pyrazol-1-ylmethylphenyl)-3-pyrimidin-2-yl-propane-1,3-dione 

Relevant academic research and scientific papers

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

1-(Aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof

Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.