317356-54-0

Basic information

• Product Name: tert-butyl 4-[N'-(2-chlorophenyl) ureido]-3-methylphenylacetate
• Synonyms: tert-butyl 4-[N'-(2-chlorophenyl) ureido]-3-methylphenylacetate
• CAS NO: 317356-54-0
• Molecular Weight: 374.867
• Mol File: 317356-54-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-[N'-(2-chlorophenyl) ureido]-3-methylphenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-[N'-(2-chlorophenyl) ureido]-3-methylphenylacetate(317356-54-0)
• EPA Substance Registry System: tert-butyl 4-[N'-(2-chlorophenyl) ureido]-3-methylphenylacetate(317356-54-0)

Safety Data

• Hazardous Substances Data: 317356-54-0(Hazardous Substances Data)

Upstream product

• 316121-73-0 tert-butyl 4-amino-3-methylphenylacetate 
• 3320-83-0 o-chlorophenyl isocyanate 
• 35675-46-8 3-methyl-4-nitro-benzoyl chloride 
• 206874-44-4 2-Diazo-1-(3-methyl-4-nitro-phenyl)-ethanone 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 924309-88-6 tert-butyl (3-methyl-4-nitrophenyl)acetate 

Downstream Products

• 316121-86-5 (4-[N'-(2-chlorophenyl)ureido]-3-methylphenyl)acetic acid 
• 317356-55-1 methyl 4-[(2S,4S)-1-[4-[N'-(2-chlorophenyl)ureido]-3-methylphenylacetyl]-4-fluoro-2-pyrrolidinyl]methoxybenzoate 

Relevant articles and documents

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists

A series of benzoic acid derivatives was synthesized as VLA-4 antagonists. Introduction of chlorine or bromine into the 3-position on the central benzene of the diphenylurea portion as in lead compound 2 led to improvement in the pharmacokinetic properties. In particular, 12l demonstrated an acceptable plasma clearance and bioavailability in mice and rats as well as dogs (mice, CL = 18.5 ml/min/kg, F = 28 %; rats, CL = 5.2 ml/min/kg, F = 36 %; dogs, CL = 3.6 ml/min/kg, F = 55 %). Additionally, 12l exhibited potent activity with an IC50 value of 0.51 nM and efficacy by oral administration at a dosage of 10 mg/kg in a rat pleurisy model.