317384-13-7

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 325153-40-0 5-[(Z)-(dimethylamino)methylidene]-3-(4-methylphenyl)-2-thioxoimidazolidin-4-one 
• 32607-35-5 3-(4-methylphenyl)-2-thiohydantoin 
• 317384-02-4 methyl 2-{[2,2-bis(acetyl)ethenyl]amino}-3-(2-methyl-1H-indol-3-yl)prop-2-enoate 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 317384-04-6 methyl 2-amino-3-(2-methyl-1H-indol-3-yl)prop-2-enoate 

Downstream Products

• 1006727-71-4 2-(4-chlorophenyl)-8-[(Z)-1-(2-methyl-1H-indol-3-yl)methylidene]-4-phenyl-6-(4-methylphenyl)-1-thia-3,4,6,9-tetraaza-spiro[4.4]non-2-en-7-one 

Relevant academic research and scientific papers

A simple synthesis of aplysinopsin analogues by dimethylamine substitution in N,N-(dimethylamino)methylidene derivatives of five-membered heterocycles

Some new aplysinopsin analogues were prepared by a simple coupling of N,N-(dimethylamino)methylidene substituted hydantoin, thiohydantoin, and thiazolone derivatives, with indole derivatives. Configuration around the exocyclic C=C double bond was determined on the basis of long-range heteronuclear coupling constants using 2D HMBC correlation technique.

A simple stereoselective synthesis of aplysinopsin analogs

Simple and stereoselective syntheses of aplysinopsins and their analogs from either methyl 2-[(2,2-disubstituted ethenyl)amino]-3-(dimethylamino)prop-2-enoates 11 or 5-[(dimethylamino)methylidene]imidazolidine-2,4-diones 20 are described. The structures of products are established by 1H- and 13C-NMR, and NOESY spectroscopy, and X-ray crystal-structure analysis.