317818-85-2Relevant academic research and scientific papers
Synthesis method of polyketone ligand
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, (2022/03/07)
The invention provides a synthesis method of a polyketone ligand 3, 3-bis-[bis-(2-methoxyphenyl) phosphinomethyl]-1, 5-dioxa-spiro [5, 5] undecane, which comprises the following steps: a) carrying out reaction on anisole and diethyl phosphite in a solvent to obtain bis (2-methoxyphenyl) phosphine oxide; b) carrying out reduction reaction on the bis (2-methoxyphenyl) phosphine oxide obtained in the step a) in a solvent to obtain bis (2-methoxyphenyl) phosphine hydrogen; and c) reacting the bis (2-methoxyphenyl) phosphine hydrogen obtained in the step b) with 5, 5-bis (bromomethyl)-1, 5-dioxa-spiro [5, 5] undecane in a solvent under the action of alkali to obtain the polyketone ligand 3, 3-bis-[bis-(2-methoxyphenyl) phosphine methyl]-1, 5-dioxa-spiro [5, 5] undecane. Compared with the prior art, specific raw materials are selected to synthesize the polyketone ligand according to specific process steps, the reaction route is simple, needed equipment is simple, energy consumption is low, overall good interaction can be achieved, the product yield is high, quality is good, and the method is safe and easy to industrialize.
