317829-69-9

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-(3'-cyanophenyl)ethanol is used as a building block for the synthesis of various pharmaceutical drugs, leveraging its chiral nature to create essential medicines.
Used as a Chiral Auxiliary:
In the field of organic chemistry, (R)-1-(3'-cyanophenyl)ethanol is used as a chiral auxiliary in asymmetric synthesis reactions. Its role is crucial in controlling the stereochemistry of the synthesized compounds, which is vital for the development of enantiomerically pure drugs.
Used in Fragrance and Flavor Production:
(R)-1-(3'-cyanophenyl)ethanol is also utilized in the production of fragrances and flavors, capitalizing on its chemical properties to create distinct and appealing scents and tastes for various consumer products.
Used in Organic Chemistry:
Furthermore, (R)-1-(3'-cyanophenyl)ethanol finds application in the field of organic chemistry for the preparation of complex molecules. Its structural features make it a valuable component in the synthesis of intricate chemical structures with potential applications in material science, pharmaceuticals, and other advanced technologies.

Upstream product

• 6136-68-1 3-acethylbenzonitrile 

Downstream Products

• 317829-71-3 (S)-1-(3-cyanophenyl)-1-azidoethane 

Relevant academic research and scientific papers

An iron variant of the Noyori hydrogenation catalyst for the asymmetric transfer hydrogenation of ketones

We report the design of a new iron catalyst for the asymmetric transfer hydrogenation of ketones. This type of iron catalyst combines the structural characteristics of the Noyori hydrogenation catalyst (an axially chiral 2,2′-bis(phosphino)-1,1′-binaphthyl fragment and the metal-ligand bifunctional motif) and an ene(amido) group that can activate the iron center. After activation by 8 equivalents of potassiumtert-butoxide, (SA,RP,SS)-7aand (SA,RP,SS)-7bare active but nonenantioselective catalysts for the transfer hydrogenation of acetophenone and α,β-unsaturated aldehydes at room temperature in isopropanol. A maximum turnover number of 14480 was observed for (SA,RP,SS)-7ain the reduction of acetophenone. The right combination of the stereochemistry of the axially chiral 2,2′-bis(phosphino)-1,1′-binaphthyl group and the carbon-centered chiral amine-imine moiety in (SA,RP,RR)-7b′afforded an enantioselective catalyst for the preparation of chiral alcohols with moderate to good yields and a broad functional group tolerance.

Src kinase inhibitor compounds

Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.