31792-49-1

Usage

InChI:InChI=1/C15H11NO2S/c1-9-4-5-12-10(7-9)11(15(17)18)8-13(16-12)14-3-2-6-19-14/h2-8H,1H3,(H,17,18)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 106-49-0 p-toluidine 
• 127-17-3 2-oxo-propionic acid 
• 88-15-3 2-Acetylthiophene 
• 608-05-9 5-methyl-indole-2,3-dione 

Downstream Products

• 908562-64-1 C₂₁H₂₃N₃OS 
• 908562-62-9 C₂₀H₂₀N₂OS 

Relevant academic research and scientific papers

ACRIDINE AND QUINOLINE SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemo therapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and/or disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Synthesis and pharmacological properties of some quinoline derivatives

A series of 2-(2-thienyl)cinchoninic acids 3, their derivatives 5 and 4-(3-substituted-1,2,4-triazolo[3,4-b]- 1,3,4-thiaziazolo-6-yl)-2-(2-thienyl)quinolines 6 were synthesized. The structures of the newly synthesized compounds are confirmed by analytical, IR, NMR and mass spectral data. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anthelmintic activity. The results indicated that dinitrothiophene derivatives 5 are more active.