6038-19-3

Usage

Uses

Used in Pharmaceutical Industry:
DL-Homocysteinethiolactone hydrochloride is used as a chemical intermediate for the production of [specific pharmaceuticals] for [reasons related to its chemical properties or reactivity].
Specifically, it is utilized in the synthesis of:
1. Erdosteine:
DL-Homocysteinethiolactone hydrochloride is used as a precursor in the synthesis of erdosteine, a mucolytic agent used for the treatment of respiratory conditions such as chronic obstructive pulmonary disease (COPD) and acute exacerbations of bronchitis. Its role in the synthesis process is crucial for the development of this therapeutic agent.
2. Citiolone:
Additionally, DL-Homocysteinethiolactone hydrochloride serves as an intermediate in the production of citiolone, a compound with potential applications in pharmaceutical formulations. Its involvement in the synthesis of citiolone highlights its versatility and importance in the development of various medicinal compounds.

InChI:InChI=1/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m1./s1

Upstream product

• 1051970-96-7 S-HCT madelate 
• 454-29-5 2-amino-4-mercaptobutyric acid 
• 61540-11-2 3-Methyl-2-oxo-tetrahydrothiophen 
• 1195-16-0 N-acetyl-DL-homocysteinethiolactone 
• 462-10-2 DL-homocystine 
• 1120-77-0 D-homocysteine thiolactone hydrochloride 
• 31828-68-9 L-homocysteine thiolactone hydrochloride 

Downstream Products

• 84611-22-3 N-chloroacetylhomocysteine thiolactone 
• 192310-93-3 [(S)-1-(2-Oxo-tetrahydro-thiophen-3-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 166451-25-8 α-(o-azido)benzoylamino-γ-butyrothiolactone 
• 105441-18-7 2-[[N-(tetrahydro-2-oxo-thien-3-yl)amino]carbonyl]benzoic acid 
• 1051970-97-8 S-HCT ditoluoyltartrate 
• 1051970-96-7 S-HCT madelate 
• 1120-77-0 D-homocysteine thiolactone hydrochloride 
• 31828-68-9 L-homocysteine thiolactone hydrochloride 
• 52703-94-3 3-hydroxy-dihydro-thiophen-2-one 

Relevant academic research and scientific papers

Preparation Method for Homocystein Thiolactone or Selenolactone

The present invention provides an expensive reagent such as homocysteine thiolactone or selenolactone as the main intermediate of erdosteine, or an expensive reagent such as HI. More specifically, A) a homoserine lactone or N - protected homoserine is reacted with a thiocarboxylic acid metal salt or selenocarboxylic acid metal salt (RCOXM, X=S or Se). B) Step A) of producing homocysteine thiolactone or homocysteine sonoactone by deprotection of N - protected homocysteine thiolactone or N - protected homocysteine seleactone. The present invention relates to a method for producing homocysteine thiactone or homocysteine senolactone or a salt thereof by the following reaction scheme. [Reaction Scheme] Then, this time. X Is S or Se, R and R ' are independently alkyl or aryl which is C1 - C6, and M is Na or K.

Continuous production method DL-cysteine thiolactone hydrochloride (by machine translation)

The method comprises the following steps DL - reacting, methionine as raw material :(1) with DL - sulfuric acid continuously into a liquid-liquid-phase micro-channel reactor to generate, high-cysteine hydrochloride 15-18mol/L containing DL - high-cysteine hydrochloride in a hydrochloric acid system through dehydration condensation to obtain, high cystine hydrochloride DL - in a continuous circulation reaction . high cystine, is obtained by carrying out a continuous circulation reaction to a cathode chamber, DL - of a plate-and-frame type electrolytic cell in a hydrochloric acid system through a continuous circulation reaction to complete DL - collection of cysteine hydrochloride in a hydrochloric acid system through dehydration and condensation reaction, so as to form DL - high-cysteine hydrochloride in the next step; DL - (1) ;(2). The. method comprises the following steps of: continuously circulating the cathode, solution, from, the liquid-phase micro-channel reactor; and carrying out a reduction reaction in a hydrochloric acid system through a liquid-liquid-phase micro-channel reactor. (by machine translation)

DL-homocysteine thiolactone hydrochloride and preparation method and applications thereof

The invention belongs to the technical field of medicine, and specifically relates to DL-homocysteine thiolactone hydrochloride and a preparation method and applications thereof. The synthesis methodof DL-homocysteine thiolactone hydrochloride comprises following steps: taking 2-methyl-4-chlorobutyryl chloride as the raw material to prepare an intermediate; distilling the intermediate, collectingdistillate; mixing the distillate with iodine and ammonia water to carry out reactions; and finally re-crystallizing and purifying the reaction product to obtain DL-homocysteine thiolactone hydrochloride. According to the synthesis method, 2-methyl-4-chlorobutyryl chloride is taken as the raw material to prepare DL-homocysteine thiolactone hydrochloride; and the preparation method has the advantages of low cost, small environmental pressure, safe and convenient production, and high yield, and is suitable for large scale production.

Novel synthetic method of DL-homocysteinethiolactone hydrochloride

The invention discloses a novel synthetic method of DL-homocysteinethiolactone hydrochloride. According to the novel synthetic method, DL-methionine and metallic sodium are subjected to reduction reaction, an obtained reduction product is subjected to desalting, and is subjected to condensation de-watering in the presence of dilute hydrochloric acid so as to obtain the DL-homocysteinethiolactone hydrochloride. DL-homocysteine is obtained via one-step synthesis from methionine, and DL-homocysteinethiolactone hydrochloride is obtained via condensation of DL-homocysteine under acid conditions, so that a re-reduction process of conversion of DL-methionine into DL-homocysteine in the prior art is avoided, reaction steps are reduced, harsh high temperature reaction conditions are avoided, release of hypertoxic gas and production of a large amount of high-salt waste water are reduced, three waste discharge is reduced, and a large amount of energy consumption is reduced; and in addition, the medium used in the novel synthetic method can be recycled, and cost is reduced. The novel synthetic method is capable of satisfying green and environment-friendly technology requirements; operation is simple; preparation is convenient; cost is low; and the novel synthetic method is suitable for industrialized large scale production.

Process for the resolution of homocysteine-thiolactone

The present invention relates to a process for the preparation of enantiomerically pure homocysteine-γ-thiolactone comprising optical resolution of racemic homocysteine-γ-thiolactone (I) with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.