318293-18-4Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists
Fraga, Aline G.M.,Rodrigues, Carlos R.,De Miranda, Ana L.P.,Barreiro, Eliezer J.,Fraga, Carlos A.M.
, p. 285 - 290 (2000)
This paper describes the synthesis and the antiplatelet properties of new heterotricyclic N-acylhydrazone derivatives (7a-e), structurally analogous to known hetrazepinic PAF antagonists, exploring molecular hybridization as a tool for molecular designing. The synthetic route employed to access compounds (7a-e) used, as starting material, the previously described methyl 3-hydroxy-8-methyl-6-phenyl-6H-pyrazolo[3,4-b]thieno[2,3-d]pyridine-2-carboxylate derivative. The results from inhibitory effects of these novel acylhydrazone derivatives (7a-e) upon PAF-induced platelet aggregation, indicated that all compounds present a significant antithrombotic profile. Copyright (C) 2000 Elsevier Science B.V.
