3183-55-9

Upstream product

• 931-97-5 1-hydroxy-1-cyclohexanecarbonitrile 
• 1123-27-9 1-(1-hydroxycyclohexyl)ethan-1-one 
• 98552-85-3 1-(1-nitroethyl)cyclohexanol 
• 16112-64-4 4-Methyl-5,5-pentamethylen-2-oxazolidon 
• 24731-36-0 1-trimethylsilanyloxycyclohexanecarbonitrile 
• 134023-82-8 1-(1-Methoxyamino-ethyl)-cyclohexanol 
• 53336-53-1 1-(1-hydroxy-cyclohexyl)-ethanone oxime 

Relevant academic research and scientific papers

Electroorganic Chemistry. 144. Electroreductive Coupling of Ketones with O-Methyl Oximes, N,N-Dimethylhydrazones, amd Nitrones. A Convenient Route to Synthesis of β-Amino Alcohol

The intermolecular coupling of a variety of ketones with some types of O-methyl oximes took place when a mixture of both components was electrochemically reduced in i-PrOH with an Sn cathode.The product, β-methoxyamino alcohol was easily converted to β-amino alcohol by simple reduction.A chiral ligand effective for the enantioselective addition of diethylzinc to an aldehyde was easily obtained from the product formed by the electroreductive coupling of (-)-menthone with O-methylacetaldoxime.The intermolecular coupling of a ketone with a N,N-dimethylhydrazone or nitrone was also promoted by the electroreduction.Furthermore, the electroreductive coupling of a carbonyl group with an intramolecular O-methyl oxime moiety gave the corresponding cyclized product stereoselectively.

Electroreductive intermolecular coupling of ketones with O-methyl oximes. A convenient route to synthesis of 2-amino alcohols

The electroreduction of ketones together with O-methyl oximes gave intermolecularly coupled products, 2-methoxyamino alcohols, which were easily reduced to 2-amino alcohols.

A New Synthesis of 2-Aminoalcohols from O-Trimethylsilylated Cyanohydrins

The reaction of O-trimethylsilylated cyanohydrins with Grignard reagents, followed by reduction, represents a convenient synthesis of 2-aminoalcohols.