31846-29-4Relevant articles and documents
Synthesis of o-Nitroarylamines via Ipso Nucleophilic Substitution of Sulfonic Acids
Manne, Srinivasa Rao,Chandra, Jyoti,Mandal, Bhubaneswar
supporting information, p. 636 - 639 (2019/01/21)
A mild, efficient, and eco-friendly method for the synthesis of o-nitroarylamine from o-nitroaryl sulfonic acid via ipso nucleophilic aryl substitution by amine is described. The products have been obtained with good yields at room temperature without the assistance of any metal, activating agent, or toxic oxidant. This method is useful for racemization-free synthesis of N-aryl amino acid esters.
Pyrrolylquinoxalinediones: A new class of AMPA receptor antagonists
Lubisch,Behl,Hofmann
, p. 2887 - 2892 (2007/10/03)
Pyrrolylquinoxalinediones were synthesized and their affinities for the AMPA receptor were determined. Most compounds showed moderate to good affinities. The acetic acid derivative 8b exhibited a K(i) value of 70 nM and was equipotent to NBQX 1. Structure activity relationships are discussed. Selected compounds were tested for their potency to inhibit AMPA induced lethal convulsions in mice. In this in vivo model the compounds showed improved potency compared with NBQX.