318464-41-4

Upstream product

• 108-24-7 acetic anhydride 
• 145533-34-2 14-β-hydroxy-10-deacetylbaccatin III 

Downstream Products

• 423718-97-2 Benzoic acid (2aR,4S,4aS,6R,10S,10aR,10bS)-6,10b-diacetoxy-4a,8,8-trimethyl-7-[1-methyl-2-oxo-eth-(E)-ylidene]-5,9-dioxo-4-triethylsilanyloxy-dodecahydro-2-oxa-cyclobuta[3,4]benzo[1,2]cycloocten-10-yl ester 
• 318464-43-6 14-β-hydroxybaccatin III 1,14-carbonate 
• 675584-85-7 C₃₉H₅₀O₁₄Si 
• 496918-80-0 C₃₇H₅₂O₁₂Si 

Relevant academic research and scientific papers

14β-Hydroxy-10-deacetylbaccatin III as a convenient, alternative substrate for the improved synthesis of methoxylated second-generation taxanes

This article describes a new, convenient, improved synthesis of the 2-debenzoyl-2-m-methoxybenzoyl-7-triethylsilyl-13-oxo-14β-hydroxybaccatin III 1,14-carbonate, the key intermediate in the synthesis of two new second-generation antitumor taxanes.

Process for the preparation of a taxane derivative

The invention relates to an improved process for the synthesis of 13-(N-Boc-β-isobutylserinyl)-14-β-hydroxybaccatin III-1,14-carbonate (I), wherein carbonation of the 1,14-hydroxy groups of the baccatin skeleton is carried out with bis(trichloromethylcarb

Process for the preparation of a taxane derivative

The invention relates to an improved process for the synthesis of 13-(N-Boc-β-isobutylserinyl)-14-β-hydroxybaccatin III-1,14-carbonate (I), wherein carbonation of the 1,14-hydroxy groups of the baccatin skeleton is carried out with bis(trichloromethylcarb

TAXANE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

The invention discloses an oxazolidine intermediate for the synthesis of 14- beta -hydroxy-1,14-carbonate-baccatines bearing a 13-isoserine substituent, and a process for the preparation thereof.

Synthesis and evaluation of 14-nor-a-secotaxoids

A series of 14-nor-A-secotaxoids has been prepared from 10-deacetyl-14β-hydroxybaccatin III (3a) and some unexpected and new reactivity of the taxane system has been revealed. The observation that the final compounds were considerably less active than taxol and their 1,10-oxygen-bridged ana-logues shows that the 1,10-oxygen tether can partially compensate for the opening of ring A, and suggests that 14-norA-secotaxoids warrant further investigation as simplified taxol mimics. WILEY-VCH Verlag GmbH 2002.