423718-97-2Relevant academic research and scientific papers
Synthesis and evaluation of 14-nor-a-secotaxoids
Appendino, Giovanni,Belloro, Emanuela,Del Grosso, Erika,Minassi, Alberto,Bombardelli, Ezio
, p. 277 - 283 (2007/10/03)
A series of 14-nor-A-secotaxoids has been prepared from 10-deacetyl-14β-hydroxybaccatin III (3a) and some unexpected and new reactivity of the taxane system has been revealed. The observation that the final compounds were considerably less active than taxol and their 1,10-oxygen-bridged ana-logues shows that the 1,10-oxygen tether can partially compensate for the opening of ring A, and suggests that 14-norA-secotaxoids warrant further investigation as simplified taxol mimics. WILEY-VCH Verlag GmbH 2002.
