318499-41-1Relevant academic research and scientific papers
Process for producing α-hydroxy-carbonyl compound
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, (2008/06/13)
The invention provides a process for producing an α-hydroxy-carbonyl compound or an α-protected hydroxy-carbonyl compound by reacting a carbonyl compound (I) with a compound (II) and a compound (III). The compounds (I), (II) and (III) are defined below. R1, R2, R3and R4are an organic group. PG is a protective group for hydroxy group. Y is R4N, S or O. The product is useful in pharmacology.
A new one-pot method for the synthesis of α-siloxyamides from aldehydes or ketones and its application to the synthesis of (-)-bestatin
Nemoto, Hisao,Ma, Rujian,Suzuki, Ichiro,Shibuya, Masayuki
, p. 4245 - 4247 (2007/10/03)
(equation presented) A new one-pot method for the synthesis of α-siloxyamides is described. The three substrates, H-C(CN)2O-SiMe2t-Bu, aldehydes or ketones, and primary or secondary amines, are simply mixed in one portion in acetonitrile or ether; the α-siloxyamides are obtained within short peroids in excellent yields in many cases. As a demonstration of our method, the synthesis of (-)-bestatin was carried out.
