31867-76-2

Upstream product

• 121-33-5 vanillin 
• 141-97-9 ethyl acetoacetate 
• 5470-11-1 hydroxylamine hydrochloride 
• 1517-96-0 3-methyl-5-isoxazolone 
• 5447-76-7 ethyl 3-oxobutanate oxime 
• 89082-79-1 (E)-ethyl 2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-butanoate 

Relevant academic research and scientific papers

A simple and efficient protocol for the synthesis of 3,4-disubstituted isoxazol-5(4h)-ones catalyzed by succinic acid using water as green reaction medium

A simple and efficient protocol has been established to the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones via Knoevenagel condensation reaction. In this synthesis, succinic acid was used as an inexpensive catalyst and water as a green reaction medium

Synthetic enzyme-catalyzed multicomponent reaction for Isoxazol-5(4H)-one Syntheses, their properties and biological application; why should one study mechanisms?

In this work, we describe the application of a synthetic enzyme (synzyme) as the catalyst to promote the multicomponent synthesis of isoxazol-5(4H)-one derivatives. The catalytic system could be used up to 15 times without any notable loss of its activity

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions

Abstract: It was found that nano-SiO2–H2SO4 was catalyzed by the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and β-ketoesters toward the synthesis of α,β-unsaturated?isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allow the synthesis of several α,β-unsaturated?isoxazol-5(4H)-ones using this method. In this study, some new derivatives of isoxazolones were also synthesized and characterized. It is efficient, clean, simple, safe, and ecologically friendly. This straightforward method is cost-effective and requires no preparation of reactants. The three-component annulation was performed without using energy sources, for example, heat, ultrasound wave, and microwave irradiation. Graphic abstract: [Figure not available: see fulltext.].

A facile & convenient route for the stereoselective synthesis of Z- isoxazol-5(4H)-ones derivatives catalysed by sodium acetate: Synthesis, multispectroscopic properties, crystal structure with DFT calculations, DNA-binding studies and molecular docking s

An efficient procedure for the one-pot synthesis of 4-arylmethylene-3- methylisoxazol-5-ones from ethyl acetoacetate, hydroxylamine hydrochloride, and various aromatic aldehydes using sodium acetate as a safe, clean, and green catalyst in ethanol is repor

An expeditious synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-ones using aqueous extract of acacia concinna pods as a natural surfactant catalyst

An aqueous extract of Acacia concinna pods has been employed as a competent and effective natural surfactant type catalyst for the synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-one analogs through one-pot, three-component reaction of β-ketoester,

A green and efficient synthesis of isoxazol-5(4H)-one derivatives in water and a DFT study

A series of 4-arylmethylene-3-methylisoxazol-5(4H)-one derivatives are obtained via treating ethyl acetoacetate, hydroxylamine hydrochloride and variety of aromatic aldehyde compounds in the presence of antimony trichloride as an efficient catalyst in aqu

Fruit juice of Citrus limon as a biodegradable and reusable catalyst for facile, eco-friendly and green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones and dihydropyrano[2,3-c]-pyrazole derivatives

Abstract: Fruit juice of Citrus limon (lemon juice) has been utilized as a natural and renewable catalyst for the green and environmentally friendly preparation of 3,4-disubstituted isoxazol-5(4H)-one derivatives and 6-amino-1,4-dihydropyrano[2,3-c]-pyraz

Expeditious green synthesis of 3,4-disubstituted isoxazole-5(4H)-ones catalyzed by nano-MgO

In this work, it was found that magnesium oxide nanoparticles (nano-MgO) catalyzed one-pot three-component reaction of hydroxylamine hydrochloride with aryl aldehydes (or heteroaryl aldehydes) and β-oxoesters to synthesize some biologically active isoxazole-5(4H)-one-based heterocycles. The reactions were completed using 3?mol% catalyst loading in aqueous medium at room temperature. Nano-MgO was synthesized by precipitation and hydrothermal treatment of aqueous salt solution. The structure of the nano-MgO was characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses. The presented environmentally friendly heterocyclization offers some interesting merits, including safety, high product yield, mild conditions, low cost, minimal waste, good atom efficiency, catalyst recoverable, energy efficiency, avoidance of hazardous organic solvents, and easy workup.

DABCO functionalized dicationic ionic liquid (DDIL): A novel green benchmark in multicomponent synthesis of heterocyclic scaffolds under sustainable reaction conditions

A novel DABCO functionalized dicationic ionic liquid (DDIL) has been synthesized using diazabicyclo[2,2,2]octane (DABCO), 1,3-dichloro-2-propanol and NaBF4 in acetonitrile. The IL was fully characterized by IR, NMR and mass spectroscopic techniques. The presence of BF4? anion in IL was confirmed by 19F NMR and also supported by mass analysis. The TGA analysis showed that the IL is thermally stable up to 180?°C temperature. We demonstrated that the presence of the tertiary nitrogen sites and hydroxyl group in the DDIL network enhances the overall activity of DDIL. These make them compatible for base catalyzed one pot multicomponent synthesis of ortho-amino carbonitriles and 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones under grinding without solvent. In addition the activity of DDIL was also studied for synthesis of tetrahydrobenzo[b]pyrans under ultrasound irradiation in water. Furthermore the DDIL was easily recoverable and recyclable many times with modest decrease in activity.

Phthalimide-N-oxyl salts: Efficient organocatalysts for facile synthesis of (Z)-3-methyl-4-(arylmethylene)-isoxazole-5(4H)-one derivatives in water

Green and simple protocols have been developed for the synthesis of (Z)-3-methyl-4-(arylmethylene)isoxazole-5(4H)-one derivatives in the presence of tetrabutylammonium or potassium salts of phthalimide-N-oxyl, as transition metal-free catalysts, through t