318730-48-2Relevant academic research and scientific papers
1-Oxacephem-based human chymase inhibitors: Discovery of stable inhibitors in human plasma
Aoyama, Yasunori,Uenaka, Masaaki,Konoike, Toshiro,Iso, Yasuyoshi,Nishitani, Yasuhiro,Kanda, Akiko,Naya, Noriyuki,Nakajima, Masatoshi
, p. 2403 - 2406 (2007/10/03)
1-Oxacephem derivatives were evaluated as a novel series of chymase inhibitors. The structure-activity relationship studies of 1-oxacephems led to compounds 15, which exhibited 27 nM inhibition of human chymase and improvement of stability in human plasma (t(1/2) 1.5 h). (C) 2000 Elsevier Science Ltd.
