318955-64-5

Upstream product

• 67-62-9 O-Methylhydroxylamin 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 52322-76-6 1,3-diphenyl-3-methoxyaminopropan-1-one 
• 94-41-7 benzalacetophenone 

Downstream Products

• 74280-88-9 (2S,3R)-phenyl-(3-phenylaziridin-2-yl)methanone 

Relevant academic research and scientific papers

Heterobimetallic Catalysis in Asymmetric 1,4-Addition of O-Alkylhydroxylamine to Enones

A heterobimetallic YLi3tris(binaphthoxide) catalyst (YLB) promoted a 1,4-addition of O-methylhydroxylamine in high enantiomeric excess (up to 97% ee). Catalyst loading was reduced to as little as 0.5 mol %, still affording the 1,4-adduct in 96%

Mechanistic studies of a reaction promoted by the [YLi 3{tris(binaphthoxide)}] complex: Are three 1,1′-bi-2-naphthol units in a rare-earth-alkali-metal heterobimetallic complex necessary?

The power of three: Mechanistic studies based on the kinetic profiles of the catalytic asymmetric 1,4-addition of an amine to chalcone revealed that all three binol ligands of the [YLi3{tris(binaphthoxide)}] complex 1 are involved in the active

Air- and water-tolerant rare earth guanidinium BINOLate complexes as practical precatalysts in multifunctional asymmetric catalysis

Shibasaki's REMB catalysts (REMB; RE = Sc, Y, La-Lu; M = Li, Na, K; B = 1,1′-bi-2-naphtholate; RE/M/B = 1/3/3) are among the most enantioselective asymmetric catalysts across a broad range of mechanistically diverse reactions. However, their widespread us

PRECATALYST FOR SHIBASAKI'S RARE EARTH METAL BINOLATE CATALYSTS

Disclosed herein are schemes for the synthesis of novel hydrogen-bonded rare earth- BINOLate precatalyst complexes, the precatalysts, per se, and their application for the generation of anhydrous REMB catalysts by cation-exchange from metal halides.

Lewis acid-Lewis acid heterobimetallic cooperative catalysis: Mechanistic studies and application in enantioselective Aza-Michael reaction

The full details of a catalytic asymmetric aza-Michael reaction of methoxylamine promoted by rare earth-alkali metal heterobimetallic complexes are described, demonstrating the effectiveness of Lewis acid-Lewis acid cooperative catalysis. First, enones we

Chiral rare earth metal complex-catalyzed conjugate addition of O-alkylhydroxylamines. An efficient synthetic entry into optically active 2-acyl aziridines

The conjugate addition of O-alkylhydroxylamines to α,β-unsaturated ketones is effectively catalyzed by chiral rare earth metal complexes to afford the corresponding β-amino ketones with high enantioselectivities (up to 99% ee) in almost quantitative yields, which are, upon treatment with a base catalyst, quantitatively converted into the 2-acyl aziridines without losing their enantiopurities. The protocol is highly practical thus providing an easy access to enantiopure 2-acyl aziridines and their derivatives in good quantities.

Catalytic conversion of conjugated enones into optically active α-keto aziridines using chiral rare earth metal complexes

Optically active N-unsubstituted α-keto aziridines 2 were synthesized from conjugated enones 1 via the Sc[(R)-BNP]3-catalyzed enantioselective Michael addition of O-methylhydroxylamine followed by the La(O-i-Pr)3-catalyzed ring closu