74280-88-9

Basic information

• Product Name: Methanone, phenyl[(2S,3R)-3-phenyl-2-aziridinyl]-
• CAS NO: 74280-88-9
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Mol File: 74280-88-9.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: Methanone, phenyl[(2S,3R)-3-phenyl-2-aziridinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, phenyl[(2S,3R)-3-phenyl-2-aziridinyl]-(74280-88-9)
• EPA Substance Registry System: Methanone, phenyl[(2S,3R)-3-phenyl-2-aziridinyl]-(74280-88-9)

Safety Data

• Hazardous Substances Data: 74280-88-9(Hazardous Substances Data)

Upstream product

• 614-47-1 1,3-diphenyl-propen-3-one 
• 318955-64-5 (S)-3-(methoxyamino)-1,3-diphenyl-1-propanone 
• 502621-40-1 (3S)-1,3-diphenyl-3-diphenylmethoxyaminopropan-1-one 
• 52322-76-6 1,3-diphenyl-3-methoxyaminopropan-1-one 
• 36744-90-8 S,S-Diphenylsulfilimine 
• 94-41-7 benzalacetophenone 
• 611-91-6 2,3-dibromo-1,3-diphenylpropane-1-one 
• 124-41-4 sodium methylate 

Downstream Products

• 128730-62-1 N-((2R,3S)-2-Benzoyl-3-phenyl-aziridine-1-carbothioyl)-4-fluoro-benzamide 
• 109830-96-8 trans-1-phenylcarbamoyl-2-benzoyl-3-phenylaziridine 
• 109831-17-6 Phenyl-((4R,5S)-5-phenyl-2-phenylamino-4,5-dihydro-thiazol-4-yl)-methanone 
• 72735-44-5 (2R*,3R*) phenyl-3 (phenyl-1 vinyl)-2 aziridine 
• 87790-74-7 (2R*,3R*) phenyl-3 (ethoxycarbonyl-2 phenyl-1 vinyl)-2 aziridine 
• 84033-42-1 ethyl 2-benzoyl-5-phenyl-1H-pyrrole-3-carboxylate 
• 84033-41-0 Ethyl-5-benzoyl-2-phenyl-1H-pyrrole-3-carboxylate 
• 71533-06-7 C₁₅H₁₅NO 
• 24290-58-2 trans-1,2-di-benzoyl-3-phenylaziridine 
• 100-52-7 benzaldehyde 
• 24806-73-3 ((anti)-2,4-diphenyl-4,5-dihydrooxazol-5-yl)(phenyl)methanone 
• 24294-71-1 1,4-diphenyl-4-benzoyloxy-2-azabutadiene 

Relevant articles and documents

Aminopyridinium iodide as a NH transferring agent for the synthesis of 2-aroyl-3-aryl aziridines

A new approach for the synthesis of N-H ketoaziridines is described. 1-aminopyridinium iodide as a NH transferring agent provides a straightforward access to the 2-aroyl-3-arylaziridines from the corresponding 1,3-diarylprop-2-en-1-one. A possible general mechanism involving the N-N ylide is proposed.

Asymmetric aziridination of chalcone promoted by binaphthalene-based chiral amines

Aminimines derived in situ from a number of enantiomerically pure binaphthalene-based tertiary amines have been used for the asymmetric aziridination of chalcone, providing N-unprotected aziridines with ee values of up to 43%. A chiral hydrazinium salt has been isolated for the first time and shown to provide similar yield and enantioselectivity to the in situ process in reaction with chalcone. Georg Thieme Verlag Stuttgart, New York.

Amine-promoted, organocatalytic aziridination of enones

(Chemical Equation Presented) A novel method is presented using N-N ylides (prepared by in situ amination of a tertiary amine) for the aziridination of a range of enone systems. The amine may be used sub-stoichiometrically, and promising levels of enantioselectivity are observed with quinine as promoter.