319-56-2

Basic information

• Product Name: 4,4,4-trifluoro-1-(3-methylthiophen-2-yl)butane-1,3-dione
• CAS NO: 319-56-2
• Molecular Formula: C₉H₇F₃O₂S
• Molecular Weight: 236.2109
• Mol File: 319-56-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 284.5°C at 760 mmHg
• Flash Point: 125.8°C
• Density: 1.363g/cm³
• Vapor Pressure: 0.00297mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: 4,4,4-trifluoro-1-(3-methylthiophen-2-yl)butane-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,4-trifluoro-1-(3-methylthiophen-2-yl)butane-1,3-dione(319-56-2)
• EPA Substance Registry System: 4,4,4-trifluoro-1-(3-methylthiophen-2-yl)butane-1,3-dione(319-56-2)

Safety Data

• Hazardous Substances Data: 319-56-2(Hazardous Substances Data)

Upstream product

• 13679-72-6 2-acetyl-3-methylthiophene 
• 383-63-1 ethyl trifluoroacetate, 

Relevant articles and documents

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles

To identify potent and selective calcium-release-activated calcium (CRAC) channel inhibitors, we examined the structure-activity relationships of the pyrazole and thiophene moieties in compound 4. Compound 25b was found to exhibit highly potent and selective inhibitory activity for CRAC channels and further modifications of the pyrazole and benzoyl moieties of compound 25b produced compound 29. These compounds were potent inhibitors of IL-2 production in vitro and also acted as inhibitors in pharmacological models of diseases resulting from T-lymphocyte activation, after oral administration.