27983-42-2

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 6-oxohexanoate is used as a reagent for the design and synthesis of anti-cancer agents. It plays a crucial role in the development of multi-acting inhibitors against various targets, such as HDAC, FLT3, and JAK2. These inhibitors are essential in the treatment of cancer, as they help regulate cellular processes and prevent uncontrolled cell growth.
Ethyl 6-oxohexanoate is also used as a reagent in the synthesis of other pharmaceutical agents. Its versatility in chemical reactions allows it to be a key component in the development of various drugs, contributing to the advancement of medical treatments and therapies.

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 5400, 1987 DOI: 10.1021/jo00233a018Tetrahedron Letters, 30, p. 5329, 1989 DOI: 10.1016/S0040-4039(01)93778-5

Upstream product

• 1073930-92-3 5-(ethoxycarbonyl)pentyl 1-naphthyl selenide 
• 1192601-83-4 5-(ethoxycarbonyl)pentyl phenyl telluride 

Downstream Products

• 49850-32-0 ethyl 4-(1H-indol-3-yl) butanoate 
• 7394-80-1 4-(5-benzyloxy-indol-3-yl)-butyric acid 
• 122850-01-5 7-(3',4'-dimethoxyphenyl)heptanoic acid 
• 122849-98-3 7-(2,3-dimethoxyphenyl)heptanoic acid 
• 106112-64-5 7,7-bis(phenylthio)hept-6-enal 
• 918310-90-4 2-[1-(tert-butyl-dimethyl-silanyloxy)-11-ethoxycarbonyl-7-hydroxy-3-methyl-undec-5-ynyl]-8,10-dimethyl-3-triethylsilanyloxy-1-oxa-6-aza-spiro[4.5]decane-6-carboxylic acid benzyl ester 
• 122849-99-4 methyl 7-(2,3-dimethoxyphenyl)heptanoate 
• 122850-02-6 methyl 7-(3,4-dimethoxyphenyl)heptanoate 
• 105-60-2 caprolactam 
• 60-32-2 6-aminohexanoic acid 
• 1088669-94-6 C₂₀H₂₉NO₅S 
• 1181216-41-0 C₃₅H₄₁NO₅ 
• 1224869-37-7 ethyl {1-[2-(3,4-dimethoxyphenyl)ethyl]-5-[3-(ethoxycarbonyl)propyl]-1,2,3,4-tetrahydropyridin-4-yl}acetate 
• 1224869-32-2 ethyl (1-benzyl-5-[3-(ethoxycarbonyl)propyl]-1,2,3,4-tetrahydropyridin-4-yl)acetate 

Relevant academic research and scientific papers

Sunlight oxidation of alkyl aryl tellurides to the corresponding carbonyl compounds: A new carbonyl precursor

Alkyl aryl tellurides were efficiently transformed to the corresponding carbonyl compounds by photo-oxidation with sunlight without affecting various functional groups in the alkyl moiety. The tellurides can be used as a new carbonyl precursor, and the photolysis can be conducted without special equipment for light sources.

Facile photochemical transformation of alkyl aryl selenides to the corresponding carbonyl compounds by molecular oxygen: Use of selenides as masked carbonyl groups

(Chemical Equation Presented) Alkyl aryl selenides with and without functional groups on the alkyl group were transformed efficiently into the corresponding carbonyl compounds, particulary primary alkyl aryl selenides in good yields, by a simple photolysis in the presence of air or oxygen. This transformation can be conducted without protection of functional groups. The yield of carbonyl compounds was much affected by the solvent viscosity, reaction temperature, concentration of dissolved oxygen in the solvents, wavelength of light, and structure of the aryl substituents. The present study indicates that aryl selenides can be considered as a masked carbonyl group that can be easily converted to a carbonyl group by very mild reaction conditions even in the presence of various unprotected functional groups. Therefore, this functional group transformation can be used as an important tool in organic synthesis due to its simplicity and mild reaction condition.