319442-16-5

Basic information

• Product Name: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-
• Synonyms: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-
• CAS NO: 319442-16-5
• Molecular Formula: C₇H₅ClN₂S
• Molecular Weight: 184.646
• EINECS: 200-589-5
• Mol File: 319442-16-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 208℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.445
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.99±0.40(Predicted)
• CAS DataBase Reference: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(319442-16-5)
• EPA Substance Registry System: Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-(319442-16-5)

Safety Data

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45
• WGK Germany: 3
• Hazardous Substances Data: 319442-16-5(Hazardous Substances Data)

Usage

Description

Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl-, also known as a member of the thienopyrimidine family, is a chemical compound with the molecular formula C8H6ClN3S. It features a thieno ring fused to a pyrimidine ring, with a chlorine atom and a methyl group attached at specific positions. This versatile compound is known for its potential applications in medicinal chemistry and drug discovery.

Uses

Used in Pharmaceutical Industry:
Thieno[3,2-d]pyrimidine, 4-chloro-2-methylis used as a building block for the synthesis of various drugs and bioactive molecules. Its unique structure and functional groups make it a valuable component in the development of new therapeutic agents.
Used in Medicinal Chemistry:
Thieno[3,2-d]pyrimidine, 4-chloro-2-methylis studied for its potential pharmacological properties, including anti-cancer and anti-inflammatory activities. Its ability to modulate biological pathways and target specific receptors makes it a promising candidate for the treatment of various diseases.
Used in Drug Discovery:
As a versatile compound, Thieno[3,2-d]pyrimidine, 4-chloro-2-methylplays a crucial role in drug discovery. Researchers utilize its chemical properties to design and optimize new drug candidates, aiming to improve their efficacy, selectivity, and safety profiles. Thieno[3,2-d]pyrimidine, 4-chloro-2-methylserves as a valuable tool in the ongoing quest to develop innovative therapeutics for unmet medical needs.

InChI:InChI=1/C7H5ClN2S/c1-4-9-5-2-3-11-6(5)7(8)10-4/h2-3H,1H3

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 22288-79-5 3-acetylamine-2-thiophenecarboxylic acid methyl ester 
• 1037297-94-1 3-acetamidothiophene-2-carboxamide 
• 147123-47-5 3-aminothiophene-2-carboxamide 
• 1611471-26-1 ethyl 3-amino-2-thiophene-2-carboxylate hydrochloride 
• 18678-13-2 2-methyl-3H-thieno[3,2-d]pyrimidin-4-one 
• 18678-13-2 2-methylthieno[3,2-d]pyrimidin-4-ol 

Downstream Products

• 935843-00-8 N-(2,5-dimethoxyphenyl)-2-methylthieno[3,2-d]pyrimidin-4-amine 
• 936837-05-7 N-(4-methoxyphenyl)-N,2-dimethylthieno[3,2-d]pyrimidin-4-amine 

Relevant articles and documents

Thienopyrimidine derivative as an active ingredient a plant disease control agent (by machine translation)

[Problem] in plant disease resistance-inducing gene expression found thienopyrimidine derivative effect, utilizing the thienopyrimidine derivatives, injuries to plant disease organisms[Solution] some of the thienopyrimidine derivatives, such as gene expression in a plant disease-resistance gene to induce PR-a 1, therefore cruciferous vegetables against plant diseases caused by pathogenic bacillus anthracis, exhibiting excellent control effect was found. [Drawing] no (by machine translation)

MONOCYCLIC, THIENO, PYRIDO, AND PYRROLO PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE OF THE SAME

The present invention provides monocyclic, thieno, pyrido and pyrrolo pyrimidine compounds. Pharmaceutical compositions comprising one or more of these compounds and optionally comprising a pharmaceutically acceptable salt or hydrate of one or more of the compounds are provided. Preferably, these pharmaceutical compositions further comprise at least one pharmaceutically acceptable carrier. Methods of treating a patient having cancer are provided wherein a therapeutically effective amount of one or more of these compounds or pharmaceutical compositions are administered to the patient.

Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold

A series of novel thienopyrimidin-4-amines have been synthesized and evaluated as phosphodiesterase (PDE) inhibitors. A rationale for the observed selectivity against PDE7 has been obtained from molecular modelling studies on the most active compounds. This journal is the Partner Organisations 2014.