319442-18-7

Basic information

• Product Name: Ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate
• Synonyms: Ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate
• CAS NO: 319442-18-7
• Molecular Formula: C₉H₇ClN₂O₂S
• Molecular Weight: 242.685
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 319442-18-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 395.188°C at 760 mmHg
• Flash Point: 192.803°C
• Appearance: /
• Density: 1.463g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: Ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate(319442-18-7)
• EPA Substance Registry System: Ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate(319442-18-7)

Safety Data

• Hazardous Substances Data: 319442-18-7(Hazardous Substances Data)

Usage

General Description

Ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate, also known as simply ethyl 4-chlorothienopyrimidine-2-carboxylate, is a chemical compound that belongs to the class of thieno[3,2-d]pyrimidines. It is commonly used in the field of organic synthesis as a key building block for the preparation of various biologically active compounds and pharmaceuticals. Ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate has shown potential as an anti-inflammatory and anti-cancer agent in preclinical studies. Its chemical structure and reactivity make it a valuable tool for drug discovery and development. The synthesis and characterization of ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate are well-documented in the scientific literature, and it continues to be an important compound in medicinal and synthetic chemistry research.

InChI:InChI=1/C9H7ClN2O2S/c1-2-14-9(13)8-11-5-3-4-15-6(5)7(10)12-8/h3-4H,2H2,1H3

Upstream product

• 319442-19-8 ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-2-carboxylate 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 

Downstream Products

• 1362710-44-8 (4-chlorothieno[3,2-d]pyrimidin-2-yl)(4-fluorophenyl)methanone 
• 1362709-96-3 1-(4-fluorophenyl)-1-(4-(5-methyl-1H-pyrazol-3-ylamino)thieno[3,2-d]pyrimidin-2-yl)ethanol 
• 1362709-98-5 2-((4-fluorophenyl)(methoxy)methyl)-N-(5-methyl-1H-pyrazol-3-yl)thieno[3,2-d]pyrimidin-4-amine 
• 1362709-70-3 (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)thieno[3,2-d]pyrimidin-2-yl)methanone 
• 1362709-72-5 (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)thieno[3,2-d]pyrimidin-2-yl)methanol 

Relevant articles and documents

ALKYNYL ALCOHOLS AND METHODS OF USE

The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are thienopyridine and thienopyrimidine compounds of formula (I) for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising