319493-66-8

Basic information

• Product Name: 5-[2-(2-chloroethyl)phenyl]dihydrofuran-2-one
• Synonyms: 5-[2-(2-chloroethyl)phenyl]dihydrofuran-2-one
• CAS NO: 319493-66-8
• Molecular Weight: 224.687
• Mol File: 319493-66-8.mol

Chemical Properties

• CAS DataBase Reference: 5-[2-(2-chloroethyl)phenyl]dihydrofuran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-(2-chloroethyl)phenyl]dihydrofuran-2-one(319493-66-8)
• EPA Substance Registry System: 5-[2-(2-chloroethyl)phenyl]dihydrofuran-2-one(319493-66-8)

Safety Data

• Hazardous Substances Data: 319493-66-8(Hazardous Substances Data)

Upstream product

• 10138-10-0 ethyl 4-oxobutanoate 
• 75534-18-8 1-bromo-2-(2-chloro-ethyl)benzene 

Relevant articles and documents

Development of a protocol for eight- and nine-membered ring synthesis in the annulation of sp2,sp3-hybridized organic dihalides with keto esters

A protocol has been developed in which annulation reactions of various dihalides with keto esters can be carried out to provide entry to eight- and nine-membered carbocycles. In this process wherein one alkenyl- or aryl bromide and a tethered alkyl chloride comprise the organic dihalide, a selective metal - halogen exchange reaction between the sp2-hybridized bromide and an organolithium initiates the process. Transmetalation to an organoytterbium reagent generates a species that undergoes selective carbonyl addition to the ketone of the keto ester, creating a lactone intermediate. Subjection of the resulting chloroalkyl lactone to intramolecular reductive coupling with samarium(II) iodide completes the desired annulation.