319494-01-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 319494-00-3 (2S,3R,4S)-4-Amino-2-(4-methoxy-phenyl)-5-oxo-tetrahydro-furan-3-carboxylic acid methyl ester 
• 19310-29-3 3-(4-methoxyphenyl)acrylic acid methyl ester 
• 319493-99-7 (2S,3R,3aS,7S)-2-(4-Methoxy-phenyl)-4-oxo-7-phenyl-hexahydro-isoxazolo[3,2-c][1,4]oxazine-3-carboxylic acid methyl ester 

Downstream Products

• 319494-02-5 (2S,3S)-2-tert-Butoxycarbonylamino-3-(4-methoxy-benzyl)-succinic acid 4-methyl ester 
• 319494-05-8 (2S,3S)-2-tert-Butoxycarbonylamino-3-(2-hydroxy-ethyl)-succinic acid 1-benzyl ester 4-methyl ester 
• 319494-04-7 (2S,3S)-2-tert-Butoxycarbonylamino-3-methoxycarbonyl-pentanedioic acid 1-benzyl ester 
• 319494-03-6 (2S,3S)-2-tert-Butoxycarbonylamino-3-(4-methoxy-benzyl)-succinic acid 1-benzyl ester 4-methyl ester 

Relevant academic research and scientific papers

Stereocontrolled synthesis of multi-functionalized β-substituted α-amino acids: Nitrone cycloaddition approach

Syn- and anti-β-substituted α-amino acids 1 and 2 were synthesized by employing nitrone-cycloaddition. The stereochemistries required were controlled via a (Z)-nitrone-exo transition state for syn-amino acid 1 and via an (E)-nitrone-exo transition state for anti-amino acid 2, respectively.