31953-81-8Relevant academic research and scientific papers
Fluorescent, synthetic amphiphilic heptapeptide anion transporters: Evidence for self-assembly and membrane localization in liposomes
You, Lei,Gokel, George W.
scheme or table, p. 5861 - 5870 (2009/05/31)
Synthetic anion transporters (SATs) of the general type (n-C 18H37)2N-COCH2OCH 2CO-(Gly)3-Pro-(Gly)3-O-n-C7H 15, 1, are amphiphilic peptides that form anion
Cation dependence of chloride ion complexation by open-chained receptor molecules in chloroform solution
Pajewski, Robert,Ferdani, Riccardo,Pajewska, Jolanta,Li, Ruiqiong,Gokel, George W.
, p. 18281 - 18295 (2007/10/03)
Seventeen peptides, most having the sequence GGGPGGG, but differing in the C- and N-terminal ends, have been studied as anion-complexing agents. These relatively simple, open-chained peptide systems interact with both chloride and the associated cation. Changes in the N- and C-terminal side chains appear to make little difference in the efficacy of binding. NMR studies suggest that the primary interactions involve amide NH contacts with the chloride anion, and CD spectral analyses suggest a concomitant conformational change upon binding. Changes in binding constants, which are expected in different solvents, also suggest selective solvent interactions with the unbound host that helps to preorganize the open-chained peptide system. Significant differences are apparent in complexation strengths when the heptapeptide chain is shortened or lengthened or when the relative position of proline within the heptapeptide is varied.
