28310-65-8

Usage

Uses

Used in Peptide Synthesis:
BOC-PRO-ONP is used as a building block in peptide synthesis for the incorporation of the amino acid proline into peptide sequences. The BOC protecting group ensures that the amino group remains unreactive during the synthesis process, preventing side reactions and facilitating the controlled stepwise assembly of peptide chains.
Used in Protein Research:
In the field of protein research, BOC-PRO-ONP is used as a component in the study of protein structure and function. The ONP group attached to the carboxyl group allows for the detection and quantification of peptides in various assays, aiding researchers in understanding the properties and interactions of proteins.
Used in Chromatography and Assays:
BOC-PRO-ONP is used as a chromogenic tag in chromatography and other analytical assays for the detection and quantification of peptides. The ONP group provides a visible signal, enabling researchers to track the presence and quantity of peptides in their samples, which is crucial for the analysis of protein expression and modifications.
Used in Pharmaceutical Development:
In the pharmaceutical industry, BOC-PRO-ONP can be utilized in the development of peptide-based drugs. Its role in peptide synthesis allows for the creation of therapeutic peptides with specific sequences and functions, potentially leading to the discovery of new treatments for various diseases.
Used in Biochemical Education and Training:
BOC-PRO-ONP serves as an educational tool in biochemical training and education. Its application in peptide synthesis and protein research provides students and researchers with hands-on experience in the techniques and principles of biochemistry, fostering a deeper understanding of the field.

InChI:InChI=1/C16H20N2O6/c1-16(2,3)24-15(20)17-10-4-5-13(17)14(19)23-12-8-6-11(7-9-12)18(21)22/h6-9,13H,4-5,10H2,1-3H3

Upstream product

• 100-02-7 4-nitro-phenol 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 147-85-3 L-proline 

Downstream Products

• 31953-81-8 Boc-PGG-OCH₂Ph 
• 133463-32-8 Boc-Pro-Val-Thr-Leu-Asp(OBzl)-Leu-Arg(NO₂)-Tyr-OMe 
• 126027-56-3 (S)-2-[(S)-5-Benzyloxycarbonylamino-1-({[(S)-1-(benzyloxycarbonylmethyl-carbamoyl)-ethylcarbamoyl]-methyl}-carbamoyl)-pentylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 78314-58-6 Boc-Pro-Lys(Z)-Pro-OCH₃ 
• 70328-13-1 Boc-Pro-Asn-OBzl 
• 35150-07-3 (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate 
• 25024-46-8 C₁₁H₁₂N₂O₄*ClH 
• 2578-57-6 N-prolylglycine 
• 51785-82-1 N-tert-butyloxycarbonyl-L-prolylglycine 
• 868759-55-1 (S)-tert-butyl 2-(tosylcarbamoyl)pyrrolidine-1-carboxylate 
• 161197-26-8 Boc-Pro-Leu-Arg(Mts)-Tyr-OBzl 
• 94249-75-9 Boc-L-Pro-L-Asp(Bzl)-NH₂ 

Relevant academic research and scientific papers

Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2- And C3-Borylated Indolines

Indole dearomatization is an important strategy to access indolines: a motif present in a variety of natural products and biologically active molecules. Herein, a method for transition-metal catalyzed regioselective dearomative arylboration of indoles to

Design, synthesis, and biological evaluation of novel stachydrine derivatives as potent neuroprotective agents for cerebral ischemic stroke

Stachydrine is a natural product with multiple protective biological activities, including those involved in preventing cancer, ischemia, and cardiovascular disease. However, its use has been limited by low bioavailability and unsatisfactory efficacy. To address this problem, a series of stachydrine derivatives (A1/A2/A3/A4/B1/B2/B3/B4) were designed and synthesized, and biological studies were carried out in vitro and in vivo. When compared with stachydrine, Compound B1 exhibited better neuroprotective effects in vitro, and significantly reduced infarction size in the model of the middle cerebral artery occlusion rat model. Therefore, Compound B1 was selected for further research on ischemic stroke. [Figure not available: see fulltext.].

Oxaziridine-mediated oxyamination of indoles: An approach to 3-aminoindoles and enantiomerically enriched 3-aminopyrroloindolines

A radical solution: A highly regioselective copper(II)-catalyzed oxyamination of N-acyl indoles with oxaziridines gave aminal products that could be converted in a single step into 3-aminoindoles and 3-aminopyrroloindolines (see scheme). When a chiral N-acyl group was used, the core fragment of some architecturally fascinating pyrroloindoline alkaloids was formed with 91% ee. Bs=benzenesulfonyl, Moc=methoxycarbonyl. Copyright

Oxo-ester mediated native chemical ligation: Concept and applications

A direct oxo-ester peptide ligation method has been developed. Through the use of an activated C-terminal para nitrophenyl ester (1), it is possible to achieve direct cysteine ligations (1 + 2 → 4). Peptide substrates incorporating bulky C-terminal amino acids (1) can be accommodated with high reaction efficiency. Copyright