31962-97-7Relevant articles and documents
The synthesis and in vitro testing of structurally novel antibiotics derived from acylnitroso Diels-Alder adducts
Nora, George P.,Miller, Marvin J.,Moellmann, Ute
, p. 3966 - 3970 (2006)
The structural similarity between β-lactam antibiotics, such as penicillin, and isoxazolidine-3,5-dicarboxylic acids led to the hypothesis that isoxazolidine-3,5-dicarboxylic acids could be effective analogs of β-lactam antibiotics. The syntheses of relevant isoxazolidine-3,5-dicarboxylic acids from acylnitroso Diels-Alder adducts and subsequent biological testing have shown that these first examples are inhibitors of Escherichia coli X580.