31983-89-8Relevant academic research and scientific papers
Synthesis and thermochemical study of quinoxaline-N-oxides: Enthalpies of dissociation of the N-O bond
Viveiros, Miguel L. F.,Freitas, Vera L. S.,Vale, Nuno,Gomes, Jose R. B.,Gomes, Paula,Da Silva, Maria D. M. C. Ribeiro
, p. 420 - 426 (2012)
The synthesis of three new quinoxaline mono-N-oxides derivatives, namely, 2-tert-butoxycarbonyl-3-methylquinoxaline-N-oxide, 2-phenylcarbamoyl-3- ethylquinoxaline-N-oxide, and 2-carbamoyl-3-methylquinoxaline-N-oxide, from their corresponding 1,4-di-N-oxid
A new facile, efficient synthesis and structure peculiarity of quinoxaline derivatives with two benzimidazole fragments
Mamedov, Vakhid A.,Zhukova, Nataliya A.,Syakaev, Victor V.,Gubaidullin, Aidar T.,Beschastnova, Tat'Yana N.,Adgamova, Dil'Bar I.,Samigullina, Aida I.,Latypov, Shamil K.
supporting information, p. 1403 - 1416 (2013/02/23)
A highly efficient and versatile method for the synthesis of quinoxaline derivatives with two benzimidazole fragments have been developed on the basis of the ring contraction of 3-(benzimidazo-2-yl)quinoxalin-2(1H)-one with 1,2-diaminobenzene and its various types of substituted and condensed derivatives. Owing to the inter- and intramolecular processes, involving self association, proton exchange, conformational, and/or tautomeric exchanges between several forms for most of the bis-benzimidazolylquinoxalines signals of bridged and neighboring carbon atoms and the hydrogen atoms of the neighboring carbon atoms of benzimidazole fragments in the NMR spectra are broadened. The conjugation between the benzimidazole fragments and the quinoxaline core of the molecules is increased from the quinoxaline derivative (10c) to its thiadiazol[f]- (17) and pyrrolo[a]-(19) annulated derivatives, resulting in a greater planarity of the molecule as a whole.
Synthesis and antimycobacterial activity of new quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives
Zarranz, Belen,Jaso, Andres,Aldana, Ignacio,Monge, Antonio
, p. 2149 - 2156 (2007/10/03)
As a continuation of our research and with the aim of obtaining new antituberculosis agents which can improve the current chemotherapeutic antituberculosis treatments, new series of quinoxaline-2-carboxamide 1,4-di-N-oxide derivatives were synthesized and
An Improved and Efficient Synthesis of Quinoxalinecarboxamide 1,4-Dioxides from Benzofuroxan and Acetoacetamides in the Presence of Calcium Salts
Stumm, G.,Niclas, H.-J.
, p. 736 - 744 (2007/10/02)
An improved and efficient method for the preparation of the title compounds 3 is described.Thus, quinoxalinecarboxamide 1,4-dioxides 3 are synthesized in high yields by reaction of benzofuroxan 1 with acetoacetamides 2 in the presence of catalytic amounts of calcium salts and ethanolamine.The reaction is assumed to involve a chelate mechanism with 4 as intermediate.Side reactions are studied by means of HPLC and TLC.
A New Synthesis of 2,3-Disubstituted Quinoxaline 1,4-Dioxide Catalyzed by Molecular Sieves
Takabatake, Tohru,Hasegawa, Minoru
, p. 529 - 530 (2007/10/02)
The syntheses of 2,3-disubstituted quinoxaline 1,4-dioxides are smoothly and efficiently carried out by the adsorption of the components on molecular sieve 3A (powder) from benzofuroxan 1 and 1,3-diketones, 3-oxoalkanoic esters, or 3-oxoalkanamides 2.
SYNTHESIS AND SPECTROSCOPIC STUDIES ON SOME NEW SUBSTITUTED 2-QUINOXALINECARBOXAMIDES AND THEIR N-OXIDES
Sabri, Salim S.,El-Abadelah, Mustafa M.,Al-Bitar, Bassam A.
, p. 699 - 711 (2007/10/02)
Series of new 2-(N-phenylcarbamoyl)-3-methylquinoxaline 1,4-dioxides (I), monoxides (II,III) and their non-oxygenated analogues (IV), as well as the corresponding series lacking the C3-methyl (V-VIII) have been prepared, and their 1H-nmr spectr
Quinoxaline derivatives
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, (2008/06/13)
The synthesis of quinoxaline and benzimidazole-N-oxides and of ester and amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a novel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.
