319905-39-0Relevant academic research and scientific papers
One - Pot synthesis of pyridines, thienopyridines, pyrrolothienopyridines and (1,8)naphthyridines under phase-transfer catalysis conditions
El-Sayed
, p. 29 - 40 (2000)
A new series of pyridines 2a,b, (1,8)naphthyridines 3a,b, and diazepines 4a,b were synthesized in one-pot reaction under phase-transfer catalysis conditions (PTC) starting with cyanoketene S,S-acetals 1 and cyanothioacetamide, cyanoacetamide or cyanoacetohydrazide in different molar ratios. The reaction of 2a with halo compounds in equimolar ratio gave thienopyridines Sa-d, while on using 1:2 molar ratio afforded pyrrolothienopyridines 6a-d. Also, bis thieno(1,8)naphthyridines 7a-d, bis-pyrrolo (1,8)naphthyridine 9 and bis(1,6)naphthyridines 10a-c were obtained by treating (1,8)naphthyridine 3a with the suitable reagents.
