One - Pot synthesis of pyridines, thienopyridines, pyrrolothienopyridines and (1,8)naphthyridines under phase-transfer catalysis conditions

Article abstract of DOI:10.1080/10426500008046608

A new series of pyridines 2_a,b, (1,8)naphthyridines 3_a,b, and diazepines 4_a,b were synthesized in one-pot reaction under phase-transfer catalysis conditions (PTC) starting with cyanoketene S,S-acetals 1 and cyanothioacetamide, cyanoacetamide or cyanoacetohydrazide in different molar ratios. The reaction of 2_a with halo compounds in equimolar ratio gave thienopyridines S_a-d, while on using 1:2 molar ratio afforded pyrrolothienopyridines 6_a-d. Also, bis thieno(1,8)naphthyridines 7_a-d, bis-pyrrolo (1,8)naphthyridine 9 and bis(1,6)naphthyridines 10_a-c were obtained by treating (1,8)naphthyridine 3_a with the suitable reagents.

Full text of DOI:10.1080/10426500008046608

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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ONE—POT SYNTHESIS OF
PYRIDINES, THIENOPYRIDINES,
PYRROLOTHIENOPYRIDINES AND
(1,8) NAPHTHYRIDINES UNDER
PHASE-TRANSFER CATALYSIS
CONDITIONS
A. M. El-Sayed a
a Chemistry Department, Faculty of Science, South
Valley University, Sohag, Egypt
Version of record first published: 04 Oct 2006
To cite this article: A. M. El-Sayed (2000): ONE—POT SYNTHESIS OF PYRIDINES,
THIENOPYRIDINES, PYRROLOTHIENOPYRIDINES AND (1,8) NAPHTHYRIDINES UNDER
PHASE-TRANSFER CATALYSIS CONDITIONS, Phosphorus, Sulfur, and Silicon and the
Related Elements, 163:1, 29-40
To link to this article: http://dx.doi.org/10.1080/10426500008046608
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