319924-81-7

Basic information

• Product Name: (S)-2,4-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene
• Synonyms: (S)-2,4-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene
• CAS NO: 319924-81-7
• Molecular Weight: 404.529
• Mol File: 319924-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2,4-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2,4-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene(319924-81-7)
• EPA Substance Registry System: (S)-2,4-dibromo-1-(3-chloro-1-phenylpropoxy)-benzene(319924-81-7)

Safety Data

• Hazardous Substances Data: 319924-81-7(Hazardous Substances Data)

Upstream product

• 615-58-7 2,4-dibromophenol 
• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 

Downstream Products

• 319924-88-4 (S)-6-methyl-3,4-dihydro-2-phenyl-2H-1-benzopyran 

Relevant articles and documents

Inter- and intramolecular Mitsunobu reaction based approaches to 2-substituted chromans and chroman-4-ones

Two approaches to optically active 2-substituted chromans and chroman-4-ones are described. The first utilized an intermolecular Mitsunobu reaction of a homochiral halopropanol and 2-bromophenol followed by cyclization to the 2-substituted chroman. In addition, a double lithiation procedure was developed to introduce additional functionality to the chroman. The second approach utilized an intramolecular Mitsunobu cyclization to give the 2-substituted chroman-4-one nucleus. The methodologies were applied to the syntheses of several biologically active natural and synthetic products.