31995-33-2Relevant academic research and scientific papers
Metal-free iodine(iii)-promoted synthesis of 2,5-diaryloxazoles
Yang, Xueying,Guo, Xin,Qin, Mingda,Yuan, Xinglong,Jing, Huanwang,Chen, Baohua
, p. 3104 - 3108 (2018)
A nonmetal-catalyzed oxidative cyclization to achieve 2,5-disubstituted oxazoles from inexpensive and readily available substituted chalcone, (diacetoxyiodo)benzene (PIDA) and ammonium acetate (NH4OAc) at room temperature is described. The reaction forms a variety of 2,5-diaryloxazoles in good to excellent yields with broad substrate scope under mild conditions without the requirement of ligands and additional bases.
