754205-30-6

Basic information

• Product Name: 2-Propen-1-one, 3-(4-ethylphenyl)-1-phenyl-
• CAS NO: 754205-30-6
• Molecular Formula: C17H16O
• Molecular Weight: 236.313
• Mol File: 754205-30-6.mol

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(4-ethylphenyl)-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(4-ethylphenyl)-1-phenyl-(754205-30-6)
• EPA Substance Registry System: 2-Propen-1-one, 3-(4-ethylphenyl)-1-phenyl-(754205-30-6)

Safety Data

• Hazardous Substances Data: 754205-30-6(Hazardous Substances Data)

Upstream product

• 25309-64-2 4-ethyl-1-iodobenzene 
• 84553-32-2 α-Methylenebenzyl formate 
• 98-86-2 acetophenone 
• 4748-78-1 4-ethylbenzylaldehyde 

Downstream Products

• 156186-40-2 3-(4-ethylphenyl)-1-phenylpropan-1-one 
• 31995-33-2 2-(4-ethylphenyl)-5-phenyloxazole 

Relevant articles and documents

1-Arylvinyl formats: A New CO Source and Ketone Source in Carbonylative Synthesis of Chalcone Derivatives

1-Arylvinyl formates as a kind of new CO surrogate have been explored for the first time. Most of the known CO precursors usually produce undesired residuals, which have to be removed. In this strategy, after CO release, the in situ generated acetophenones from 1-arylvinyl formates can be successfully applied as a good ketone source in the synthesis of chalcones with benzaldehydes via a palladium-catalyzed reductive carbonylation reaction. A variety of chalcones were isolated in satisfactory to good yields with good substrates compatibilities under mild conditions.

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

ALLOSTERIC PROTEIN KINASE MODULATORS

The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.

3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds

The modulation of protein kinase activities by low molecular weight compounds is a major goal of current pharmaceutical developments. In this line, important efforts are directed to the development of drugs targeting the conserved ATP binding site. Howeve