320-50-3

Basic information

• Product Name: 2,5-Dichlorobenzotrifluoride
• Synonyms: 2,5-DICHLORO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE;2,5-DICHLOROBENZOTRIFLUORIDE;2,5-DICHLORO-A,A,A-TRIFLUOROTOLUENE;2,5-DICHLORO TRIFLUOROMETHYLBENZENE;1,4-DICHLORO-2-(TRIFLUOROMETHYL)BENZENE;1,4-dichloro-2-(trifluoromethyl)-benzen;2,5-Dichloro-1-(trifluoromethyl)-benzene;2,5-dichloro-alpha,alpha,alpha-trifluoro-toluen
• CAS NO: 320-50-3
• Molecular Formula: C₇H₃Cl₂F₃
• Molecular Weight: 215
• EINECS: 206-276-0
• Product Categories: Chlorine Compounds;Fluorine Compounds;Aryl;Building Blocks;C7;Chemical Synthesis;Halogenated Hydrocarbons;Organic Building Blocks
• Mol File: 320-50-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 174.82°C (rough estimate)
• Flash Point: 169 °F
• Appearance: Clear colourless to light yellow liquid
• Density: 1.483 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.483(lit.)
• BRN: 1955442
• CAS DataBase Reference: 2,5-Dichlorobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dichlorobenzotrifluoride(320-50-3)
• EPA Substance Registry System: 2,5-Dichlorobenzotrifluoride(320-50-3)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-27-36/37/39-45
• RIDADR: UN 1760 8/PG 2
• WGK Germany: 3
• RTECS: CZ5553755
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 320-50-3(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

2,5-Dichlorobenzotrifluoride was used as an internal standard in the quantitative analysis of hexafluoropropylene/vinylidene fluoride copolymers by the CW (Continuous Wave)-NMR method.

InChI:InChI=1/C12H6F12O2/c13-9(14,15)7(10(16,17)18)25-5-1-2-6(4-3-5)26-8(11(19,20)21)12(22,23)24/h1-4,7-8H

Upstream product

• 98-08-8 α,α,α-trifluorotoluene 
• 98-15-7 3-chlorotrifluoromethylbenzene 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 106-46-7 para-dichlorobenzene 
• 29848-52-0 4-fluorobenzene 
• 14353-88-9 iodopentafluorobenzene bis(trifluoroacetate) 
• 76-05-1 trifluoroacetic acid 
• 2966-50-9 silver trifluoroacetate 
• 61841-46-1 2,3,5-trichlorotrifluoromethylbenzene 
• 2926-29-6 Langlois reagent 

Downstream Products

• 656-96-2 4-chloro-3-(trifluoromethyl)phenylamino aldehyde 
• 91626-53-8 4-chloro-3-(trifluoromethyl)phenylhydrazine 
• 284461-73-0 sorafenib 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 
• 53903-51-8 2-trifluoromethyl-4-chlorophenol 
• 80245-27-8 3-trifluoromethyl-4-chloro-toluene 
• 871254-76-1 2,5-dichloro-3-(trifluoromethyl)benzoic acid 

Relevant articles and documents

Method for synthesizing 2, 5-dichlorobenzotrifluoride through continuous flow catalytic chlorination

The invention provides a method for synthesizing 2, 5-dichlorobenzotrifluoride through continuous flow catalytic chlorination, and belongs to the field of synthesis processes. According to the method, o-chlorobenzotrifluoride and chlorine are taken as raw materials, and the 2, 5-dichlorobenzotrifluoride is synthesized in a continuous flow reactor with high selectivity in the presence of a catalyst. Compared with the traditional method, the synthesis method disclosed by the invention has the advantages that the selectivity is higher, the generation of byproducts is greatly reduced, the reaction time is shortened, the production efficiency is improved, the 2, 5-dichlorobenzotrifluoride with high yield and high purity is obtained, and the industrial application prospect is very good.

Phosphovanadomolybdic acid catalyzed direct C-H trifluoromethylation of (hetero)arenes using NaSO2CF3 as the CF3 source and O2 as the terminal oxidant

A direct C-H trifluoromethylation of (hetero)arenes using NaSO2CF3 (Langlois' reagent) as the CF3 source and O2 as the terminal oxidant has been developed. In the presence of catalytic amounts of phosphovanadomolybdic acids, such as H6PV3Mo9O40, various kinds of substituted benzenes and heteroaromatic compounds could be converted into the corresponding trifluoromethylated products.

Direct Perfluoroalkylation Including Trifluoromethylation of Aromatic with Perfluoro Carboxylic Acids Mediated by Xenon Difluoride

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