320-50-3

Usage

Uses

Used in Polymer Analysis:
2,5-Dichlorobenzotrifluoride is used as an internal standard in the quantitative analysis of hexafluoropropylene/vinylidene fluoride copolymers by the CW (Continuous Wave)-NMR method. Its chemical stability and distinct properties make it an ideal reference for accurate measurements and analysis in this application.
Used in Chemical Synthesis:
Due to its unique chemical structure, 2,5-Dichlorobenzotrifluoride can be utilized as a starting material or intermediate in the synthesis of various organic compounds, particularly those involving fluorination or chlorination reactions.
Used in Industrial Applications:
2,5-Dichlorobenzotrifluoride may also find use in specific industrial applications where its chemical properties, such as resistance to certain reaction conditions or its ability to act as a solvent, are advantageous.

InChI:InChI=1/C12H6F12O2/c13-9(14,15)7(10(16,17)18)25-5-1-2-6(4-3-5)26-8(11(19,20)21)12(22,23)24/h1-4,7-8H

Upstream product

• 98-15-7 3-chlorotrifluoromethylbenzene 
• 106-46-7 para-dichlorobenzene 
• 2926-29-6 Langlois reagent 
• 14353-88-9 iodopentafluorobenzene bis(trifluoroacetate) 
• 29848-52-0 4-fluorobenzene 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 76-05-1 trifluoroacetic acid 
• 98-08-8 α,α,α-trifluorotoluene 
• 2966-50-9 silver trifluoroacetate 
• 61841-46-1 2,3,5-trichlorotrifluoromethylbenzene 

Downstream Products

• 871254-76-1 2,5-dichloro-3-(trifluoromethyl)benzoic acid 
• 284461-73-0 sorafenib 
• 91626-53-8 4-chloro-3-(trifluoromethyl)phenylhydrazine 
• 656-96-2 4-chloro-3-(trifluoromethyl)phenylamino aldehyde 
• 320-51-4 4-chloro-3-trifluoromethyl-aniline 
• 53903-51-8 2-trifluoromethyl-4-chlorophenol 
• 80245-27-8 3-trifluoromethyl-4-chloro-toluene 

Relevant academic research and scientific papers

Method for synthesizing 2, 5-dichlorobenzotrifluoride through continuous flow catalytic chlorination

The invention provides a method for synthesizing 2, 5-dichlorobenzotrifluoride through continuous flow catalytic chlorination, and belongs to the field of synthesis processes. According to the method, o-chlorobenzotrifluoride and chlorine are taken as raw materials, and the 2, 5-dichlorobenzotrifluoride is synthesized in a continuous flow reactor with high selectivity in the presence of a catalyst. Compared with the traditional method, the synthesis method disclosed by the invention has the advantages that the selectivity is higher, the generation of byproducts is greatly reduced, the reaction time is shortened, the production efficiency is improved, the 2, 5-dichlorobenzotrifluoride with high yield and high purity is obtained, and the industrial application prospect is very good.

Visible-Light photoredox decarboxylation of perfluoroarene iodine(III) Trifluoroacetates for C-H trifluoromethylation of (Hetero)arenes

A scalable and operationally simple decarboxylative trifluoromethylation of (hetero)arenes with easily accessible C6F5I(OCOCF3)2 under photoredox catalysis has been developed. This method is tolerant of various (hetero)arenes and functional groups. Notably, C6F5I is recycled from the decarboxylation reaction and further used for the preparation of C6F5I(OCOCF3)2. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the application of trifluoroacetic acid in trifluoromethylation reactions.

Phosphovanadomolybdic acid catalyzed direct C-H trifluoromethylation of (hetero)arenes using NaSO2CF3 as the CF3 source and O2 as the terminal oxidant

A direct C-H trifluoromethylation of (hetero)arenes using NaSO2CF3 (Langlois' reagent) as the CF3 source and O2 as the terminal oxidant has been developed. In the presence of catalytic amounts of phosphovanadomolybdic acids, such as H6PV3Mo9O40, various kinds of substituted benzenes and heteroaromatic compounds could be converted into the corresponding trifluoromethylated products.

RELATIONSHIPS AND KINETICS OF THE EXHAUSTIVE CHLORINATION OF m-CHLOROTRIFLUOROMETHYLBENZENE AND TRIFLUOROMETHYLBENZENE

The exhaustive electrophilic chlorination of m-chlorotrifluoromethylbenzene and trifluoromethylbenzene, catalyzed by ferric chloride , was investigated on the basis of a correlation approach.The relationships governing the regulation of the reactivity of the chlorine derivatives of trifluoromethylbenzene were studied.A quantitative relation was established between the direction of chlorination and the effects of the substituents; the effects of the latter remain unchanged in the polychloro derivatives of trifluoromethylbenzene, while the overall effect is close to additive.The distribution of the isomers was determined for various degrees of substitution of trifluoromethylbenzene: monochloro, 2- , 3- , 4- ; dichloro, 2,5- , 3,4- , 2,3- , 3,5- ; trichloro, 2,3,5- and 2,4,5- , 3,4,5- , 2,3,6- , 2,3,4- ; tetrachloro-, 2,3,5,6- , 2,3,4,5- .The following derivatives are formed during the chlorination of m-chlorotrifluoromethylbenzene: dichloro, 2,5- , 3,4- , 2,3- , 3,5- ; trichloro, 2,3,5- and 2,4,5- , 3,4,5- , 2,3,6- , 2,3,4- ; tetrachloro, 2,3,5,6- , 2,3,4,5- .The distribution of the isomers agrees with the distribution calculated on the basis of the employed parameters and the additivity principle.The compositions of the products with various degrees of chlorination are given satisfactorily by kinetic curves describing a multistage system of consecutive and parallel irreversible first-order reactions.