32017-73-5

Upstream product

• 186581-53-3 diazomethane 
• 146-81-6 2-( 4'-tert-butylbenzoyl)benzoic acid 
• 67-56-1 methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 63488-10-8 4-tert-butylmagnesium bromide 
• 85-44-9 phthalic anhydride 

Relevant academic research and scientific papers

Construction of an isoquinolinone framework from carboxylic-ester-directed umpolung ring opening of methylenecyclopropanes

An interesting type of reaction involving functionalized methylenecyclopropanes (MCPs) has been revealed. Here, a nucleophilic attack of an anionic species onto a partially polarity-reversed MCP was realized by treating a neighbouring carboxylic ester tethered to the MCP and amine with KHMDS to realize an umpolung ring opening of the MCP. This work established an operationally convenient protocol for the rapid construction of isoquinolinone frameworks. This journal is