3202-77-5

Usage

Uses

Used in Pharmaceutical Industry:
4-[morpholin-4-yl(sulfanyl)methylidene]cyclohexa-2,5-dien-1-one is used as a pharmaceutical compound for its potential therapeutic applications. The presence of the morpholine and cyclohexadienone moieties may contribute to its biological activity, making it a candidate for the development of new drugs with unique mechanisms of action.
Used in Agrochemical Industry:
In the agrochemical industry, 4-[morpholin-4-yl(sulfanyl)methylidene]cyclohexa-2,5-dien-1-one is used as a potential active ingredient in the development of new pesticides or herbicides. Its chemical properties may provide novel modes of action against pests and weeds, offering alternative solutions to existing challenges in agriculture.
Used in Materials Science Research:
4-[morpholin-4-yl(sulfanyl)methylidene]cyclohexa-2,5-dien-1-one is utilized in materials science research for its potential to contribute to the development of new materials with unique properties. The combination of the morpholine and cyclohexadienone moieties may result in materials with enhanced performance characteristics, such as improved stability, reactivity, or selectivity in various applications.
Used in Chemical Synthesis:
4-[morpholin-4-yl(sulfanyl)methylidene]cyclohexa-2,5-dien-1-one serves as a key intermediate in the synthesis of other complex organic compounds. Its unique structure and functional groups make it a valuable building block for the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals, enabling the development of novel products with improved properties and applications.

Upstream product

• 110-91-8 morpholine 
• 123-08-0 4-hydroxy-benzaldehyde 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 1696-20-4 4-acetylmorpholine 

Downstream Products

• 76226-77-2 4-[Morpholin-4-yl-(quinolin-2-yl-hydrazono)-methyl]-phenol; hydriodide 
• 76226-65-8 4-(p-acetoxy-α-methylthiobenzylidene)morpholinium iodide 
• 76226-76-1 Acetic acid 4-[morpholin-4-yl-(quinolin-2-yl-hydrazono)-methyl]-phenyl ester; hydriodide 
• 1321807-47-9 4-methyl-N-((4-hydroxyphenyl)(morpholino)methylene)benzensulfonamide 
• 76226-61-4 p-acetoxythiobenzomorpholide 

Relevant academic research and scientific papers

Mixed bases mediated synthesis of thioamides in water

A mixed bases mediated protocol is developed to synthesize thioamides from N-aryl or N-alkylamide, aldehyde and elemental sulfur in water. This reaction requires no addition of external oxidant and avoids large excess of amides. Various functional groups

Method for promoting elemental sulfur to synthesize thioamide by mixed alkali in water phase

The invention provides a method for promoting elemental sulfur to synthesize a thioamide compound by a mixed alkali in a water phase, and belongs to the field of organic synthesis. According to the method, an aldehyde compound and an amide compound are us

Sulfated polyborate catalyzed Kindler reaction: a rapid, efficient, and green protocol

A rapid, green, and efficient one-pot, three-component Kindler reaction was developed using a sulfated polyborate catalyst. The method described the reaction of aldehydes, amines/ammonium acetate, and sulfur for the synthesis of thioamides using sulfated polyborate under a solvent free condition at 100?°C. The key features of the present protocol are high yields, short reaction time, easy workup, and recyclability of a catalyst which gives economical as well as ecological rewards. The present method also has an ability to tolerate a variety of functional groups. Graphical abstract: [Figure not available: see fulltext.].

Zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides: A new approach to the synthesis of amidines

The first zinc chloride catalyzed ring opening of N-arylsulfonyl aziridines by thioamides is described. Various thioamides were reacted with N-arylsulfonyl aziridines in the presence of a catalytic amount of dry zinc chloride to provide the corresponding

Willgerodt-kindler's microwave-enhanced synthesis of thioamide derivatives

The Willgerodt-Kindler reaction was applied to a series of aromatic aldehydes and ketones. The reactions were performed in a dipolar aprotic solvent (mainly DMF) in the presence of a base catalyst (4-methylmorpholine) and utilized microwave (mw) irradiation. The pulsed mw technique rather than the continuous irradiation was preferred because it limited side reactions and hydrogen sulfide production. While not always superior to the thermal activation of the reaction, the procedure involving repetitive short pulses of microwave irradiation was found to be faster and result in consistently cleaner products. The technique can be easily applied in a fast parallel synthesis process.

Infrared spectra of several thiopiperidides and thiomorpholides

Infrared spectra in the 1700-500 cm-1 region have been studied for several types of thiopiperidides (thiobenzoylpiperidides, thiocinnamoylpiperidides and phenylthioacetpiperidides) and for the corresponding thiomorpholides.Three characteristic thioamide bands were located and assigned.The behaviour of these bands on molecular complexing (with iodine as an electron acceptor) was used to support the assignments.The experimental data were discussed in terms of the theoretical results obtained by an HMO procedure.