320337-19-7

Basic information

• Product Name: (6-iodo-((4-benzyloxy)-3-bromophenyl)-quinazolin-4-yl)amine
• Synonyms: (6-iodo-((4-benzyloxy)-3-bromophenyl)-quinazolin-4-yl)amine
• CAS NO: 320337-19-7
• Molecular Weight: 532.178
• Mol File: 320337-19-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (6-iodo-((4-benzyloxy)-3-bromophenyl)-quinazolin-4-yl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (6-iodo-((4-benzyloxy)-3-bromophenyl)-quinazolin-4-yl)amine(320337-19-7)
• EPA Substance Registry System: (6-iodo-((4-benzyloxy)-3-bromophenyl)-quinazolin-4-yl)amine(320337-19-7)

Safety Data

• Hazardous Substances Data: 320337-19-7(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 191602-86-5 1-(benzyloxy)-2-bromo-4-nitrobenzene 
• 5847-59-6 2-bromo-4-nitrophenol 
• 320337-15-3 4-benzyloxy-3-bromoaniline 
• 98556-31-1 4-chloro-6-iodoquinazoline 

Downstream Products

• 320337-28-8 5-(4-(3-Bromo-4-(benzyloxy)-anilino)-quinazolin-6-yl)-furan-2-carbaldehyde 

Relevant articles and documents

Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series

Synthetic modifications on a 6-furanylquinazoline scaffold to optimize the dual ErbB-1/ErbB-2 tyrosine kinase inhibition afforded consistent SAR whereby a 4-(3-fluorobenzyloxy)-3-haloanilino provided the best enzyme potency and cellular selectivity. Changes made to the 6-furanyl group had little impact on the enzyme activity, but appeared to dramatically affect the cellular efficacy. The discovery of lapatinib emerged from this work.