32046-43-8

Basic information

• Product Name: 5-Iodopyridine-2-carboxylic acid
• Synonyms: 5-Iodopyridine-2-carboxylic acid;5-Iodopicolinic Acid;5-Iodo-2-pyridinecarboxylic acid
• CAS NO: 32046-43-8
• Molecular Formula: C6H4INO2
• Molecular Weight: 249.00593
• Product Categories: pharmacetical
• Mol File: 32046-43-8.mol

Chemical Properties

• Melting Point: 188-190 °C
• Boiling Point: 355.22oC at 760 mmHg
• Flash Point: 168.631oC
• Appearance: /
• Density: 2.124g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.46±0.10(Predicted)
• CAS DataBase Reference: 5-Iodopyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodopyridine-2-carboxylic acid(32046-43-8)
• EPA Substance Registry System: 5-Iodopyridine-2-carboxylic acid(32046-43-8)

Safety Data

• Hazardous Substances Data: 32046-43-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Iodopyridine-2-carboxylic acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a valuable building block for the development of new drugs with specific therapeutic properties.
Used in Anticancer Applications:
5-Iodopyridine-2-carboxylic acid is used as a precursor for the preparation of bis(5-iodopicolinato)oxovanadium(IV), which is an antidiabetic agent. 5-Iodopyridine-2-carboxylic acid has shown potential in managing blood sugar levels and improving the treatment of diabetes.
Used in Insulinomimetic Activity:
The zinc(II) complex with 5-Iodopyridine-2-carboxylic acid has demonstrated insulinomimetic activity, which means it can mimic the effects of insulin in the body. This property makes it a promising candidate for the development of new treatments for diabetes and related metabolic disorders.

InChI:InChI=1/C6H4INO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10)

Upstream product

• 55338-73-3 5-amino-2-cyanopyridine 
• 109-06-8 α-picoline 
• 100367-55-3 5-nitropyridine-2-carbonitrile 
• 4214-76-0 5-nitro-pyridin-2-ylamine 
• 30651-24-2 5-nitropicolinic acid 
• 4487-59-6 2-bromo-5-nitropyridine 
• 24242-20-4 5-amino-pyridine-2-carboxylic acid 
• 695-17-0 3-iodo-6-methylpyridine 

Relevant articles and documents

DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-α]IMIDAZOLE-3- CARBOXYLIC ACID AMIDES

Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

Comparison of two synthetic methods to obtain [18F] N-(2-aminoethyl)-5-fluoropyridine-2-carboxamide, a potential MAO-B imaging tracer for PET

The compound Ro 19-6327, N-(2-aminoethyl)-5-chloropyridine-2-carboxamide, is known to inhibit reversibly and site specifically the enzyme monoamine oxidase B (MAO-B). The 123I-labelled iodo-analogue N-(2-aminoethyl)-5-iodopyridine-2-carboxamide (Ro 43-0463) was investigated successfully in human volunteers by means of SPET (Single Photon Emission Tomography). We developed therefore the synthesis and radiolabelling of the corresponding fluoro-analogue N-(2-aminoethyl)-5-fluoropyridine-2-carboxamide with 18F in order to carry out PET (Position Emission Tomography) investigations of MAO-B related neuropsychiatric diseases. For this purpose two synthetic approaches leading to the electrophilic and the nucleophilic methods of 18F radiolabelling were undertaken. The nucleophilic approach appeared to be superior when factors such as precursor synthesis, beam time, specific activity and radiochemical purity of the product are considered.

The preparation of Some 4- and 5-Substituted Pyridine-2-carboxylic Acids as Fusaric Acid Analogues.

In view of future studies on the structure-activity relationships involved in the inhibition of dopamine β-hydroxylase, the authors synthetized 5-substituted picolinic acids and 4-substituted fusaric acids selected by means of a random sampling procedure suited for small series.On this occasion, they succeeded in improving markedly the well-known synthesis of 5-nitropicolinic acid via a Rosenmund-v.Braun reaction with 2-bromo-5-nitropyridine. 5-Hydroxypicolinic acid which is easily accessible in the same way could be converted into 5-alkyloxypicolinic acids by reaction with alkyl halides in DMSO in the presence of silver oxide. 4-Substituted fusaric acids became accessible via 5-n-butyl-2-methyl-4-nitropyridine-N-oxide.