32063-84-6

Upstream product

• 4554-16-9 2,3-dibromopropionitrile 
• 75-64-9 tert-butylamine 
• 1104196-24-8 t-butyl-3-N-chloroaminopropionitrile 
• 31367-72-3 1-cyanovinyl methanesulfonate 

Downstream Products

• 84269-67-0 (α-iminobenzyl)-2 t-butyl-1 aziridine 

Relevant academic research and scientific papers

Synthesis of substituted aziridines via intramolecular reactions of β-N-chloroethylamino carbanions

Simple and efficient method of synthesis of 2-alkoxycarbonyl, 2-cyano, 2-phenylsulfonyl N-alkylaziridines was elaborated via intramolecular nucleophiles substitution of chloride in 1-N-chloro-2-alkoxycarbonyl (cyano, phenylsulfonyl) ethyl amines. These su

Trimethylsilyl Cyanide - A Reagent for Umpolung, IX. Enol Esters of Acyl Cyanides: Syntheses and General Properties

According to Scheme 1 acyl cyanide-enol sulfonates 3-5, carboxylates 7-9, and phosphates 12 are synthesized on routes A-D in generally good yields.Judged by 13C NMR chemical shifts of C-3, the donor effect of the enol groups on the C=C bond decreases slightly in the order OP(O)(OEt)2 > OCO2Et > OCOCH3 > OCOCF3 > OSO2Me OSO2Ph > OSO2C4F9, but being always larger than the acceptor effect of the CN group.Reactions with nucleophiles to give 1,2-diketones (29, 30) and with radicals to form adducts 32 and 35 are described.Depending on the substituent pattern , and cycloadditions can be performed with 2f, 5f, and 12f.Different cyclopropanes 54 can be prepared from 5f.

N-Substituted aziridine-2-carboxylic acid derivatives and their immuno-stimulation compositions and methods

A 2-cyanaziridine derivative of the formula STR1 wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy; or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.

N-Substituted aziridine-2-carboxylic acid derivatives for immuno stimulation

Aziridine-2-carboxylic acid derivatives of the formula STR1 wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, and R and R1 are various organic radicals, or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R1 is a hydrogen atom, R' is not an unsubstituted cyclohexyl, alkyl or benzyl radical; or where X is a cyano group or an alkoxycarbonyl radical and R1 is a phenyl radical, R' is not an isopropyl, cyclohexyl, phenyl, benzyl or p-chlorobenzyl radical; or where R1 is a methyl radical, R1 is not a benzyl, p-chloro- or p- methoxybenzyl radical.