32078-38-9Relevant articles and documents
Self-assembly of bistriazole BDT based bolaamphiphiles into SmA phase and helical organogels
Cheng, Xiaohong,Gao, Hongfei,Liu, Yuantao,Yan, Qi,Zhang, Deling
, (2021/01/12)
Bistriazole benzo[1,2-b:4,3-b′]dithiophene (BDT) contained bolaamphiphiles have been synthesized via Sonogashira coupling and click reactions as key steps. For such compounds, the central bent bistriazole BDT core, the flexible methylene spacer led the rodlike core together with the terminal diol groups to twist to be U-shaped polar region. Micro-segregation of U-shaped polar region from the lipophilic chains generated a SmA phase. Furthermore, these compounds can act as super organogelators to gel different kinds of solvents with the lowest critical gelation concentration (CGC) of 0.2 mg/ml. Gel morphologies with scarcely reported nanostructures including nanofibers, nanobelts, nanodisks, nanotrumpets and nanotubes were firstly observed in bolaamphiphilic self-assembly system.
COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES
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, (2019/03/12)
The present disclosure relates to compounds according to Formula (I), useful for treating diseases.
PERMEABLE GLYCOSIDASE INHIBITORS AND USES THEREOF
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Page/Page column 77, (2013/12/03)
Disclosed are compounds of Formula (I), wherein each substituent of Formula (I) is defined as in the specification, pharmaceutical formulations comprising these compounds which are useful as 0-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus are useful for the treatment of certain disorders such as Alzheimer' s disease including reducing NFTs and/or hyperphosphorylated tau. Also disclosed is the use of the compounds as O-GlcNAcase imaging agents.