32078-38-9

Upstream product

• 50-00-0 formaldehyd 
• 1746-13-0 allyl phenyl ether 
• 5443-37-8 ethyl 4-(n-prop-2'-enyloxy)benzoate 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 124-63-0 methanesulfonyl chloride 
• 3256-45-9 4-allyloxybenzyl alcohol 
• 40663-68-1 4-(2-propenyloxy)benzaldehyde 

Downstream Products

• 185446-94-0 (2R,3S,4S,5R,6R)-3-(4-Allyloxy-benzyloxy)-4,5-bis-benzyloxy-6-benzyloxymethyl-2-methylsulfanyl-tetrahydro-pyran 
• 1369862-32-7 1-(allyloxy)-4-(azidomethyl)benzene 
• 464177-66-0 6-[4-((2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-3-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethoxymethyl)-phenoxy]-hexanoic acid 
• 464177-72-8 (2R,3S,4S,5R,6R)-4,5-Bis-benzyloxy-2-(4-hydroxy-benzyloxymethyl)-6-methoxy-tetrahydro-pyran-3-ol 
• 943978-25-4 4-allyloxybenzyl thiocholesteryl ether 
• 943978-24-3 4-allyloxybenzyl cholestanyl ether 
• 943978-23-2 4-allyloxybenzyl cholesteryl ether 
• 464177-71-7 (2R,3S,4S,5R,6R)-2-(4-Allyloxy-benzyloxymethyl)-4,5-bis-benzyloxy-6-methoxy-tetrahydro-pyran-3-ol 
• 172371-55-0 10,15-Dihydro-2,7,12-trimethoxy-3,8,13-tris(4-allyloxybenzyloxy)-5H-tribenzocyclononene 
• 60736-74-5 3-chloro-4-(4'-allyloxybenzyloxy)-phenylacetic acid 

Relevant academic research and scientific papers

Self-assembly of bistriazole BDT based bolaamphiphiles into SmA phase and helical organogels

Bistriazole benzo[1,2-b:4,3-b′]dithiophene (BDT) contained bolaamphiphiles have been synthesized via Sonogashira coupling and click reactions as key steps. For such compounds, the central bent bistriazole BDT core, the flexible methylene spacer led the rodlike core together with the terminal diol groups to twist to be U-shaped polar region. Micro-segregation of U-shaped polar region from the lipophilic chains generated a SmA phase. Furthermore, these compounds can act as super organogelators to gel different kinds of solvents with the lowest critical gelation concentration (CGC) of 0.2 mg/ml. Gel morphologies with scarcely reported nanostructures including nanofibers, nanobelts, nanodisks, nanotrumpets and nanotubes were firstly observed in bolaamphiphilic self-assembly system.

Methanesulfinylation of Benzyl Halides with Dimethyl Sulfoxide

A phenyltrimethylammonium tribromide-mediated nucleophilic substitution/oxygen transformation reaction of benzyl halides with DMSO has been developed. In this transition-metal-free reaction, DMSO acts as not only a solvent but also a "S(O)Me" source, thus providing a convenient method for the efficient and direct synthesis of various benzyl methyl sulfoxides.

COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES

The present disclosure relates to compounds according to Formula (I), useful for treating diseases.

Structure–Activity Relationship Studies of Vitamin D3 Analogues Containing an Ether or Thioether Linker as Hedgehog Pathway Inhibitors

The Hedgehog (Hh) signaling pathway is critical for embryonic patterning and postembryonic tissue regeneration. Constitutive pathway activation has also been linked to human malignancies such as basal cell carcinoma (BCC) and medulloblastoma; therefore, multiple small-molecule scaffolds that inhibit Hh signaling are in development. Previously, Grundmann's alcohol, also known as the “northern region” of vitamin D3 (VD3), has been identified as a moderate Hh pathway inhibitor. In this study, isomers of Grundmann's alcohol with different orientations of the C4 hydroxy group and C3α proton were investigated to determine the optimal configuration for this hexahydroindane scaffold with respect to Hh inhibition. A series of analogues containing Grundmann's alcohol linked to a substituted phenyl or benzyl ring through an ether or thioether linker were synthesized and evaluated for their anti-Hh activity. Of these, analogue 17 ((1R,3aR,4R,7aR)-1-[(R)-1,5-dimethylhexyl]-4-(4-aminophenoxy)-7a-methyloctahydro-1H-indene) demonstrated potent anti-Hh activity in Hh-dependent BCC cells and did not activate canonical vitamin D receptor signaling, demonstrating its selective nature for the Hh signaling pathway.

PERMEABLE GLYCOSIDASE INHIBITORS AND USES THEREOF

Disclosed are compounds of Formula (I), wherein each substituent of Formula (I) is defined as in the specification, pharmaceutical formulations comprising these compounds which are useful as 0-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus are useful for the treatment of certain disorders such as Alzheimer' s disease including reducing NFTs and/or hyperphosphorylated tau. Also disclosed is the use of the compounds as O-GlcNAcase imaging agents.

PERMEABLE GLYCOSIDASE INHIBITORS AND USES THEREOF

The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and/or hyperphosphorylated tau. The invention is also directed to use of the compounds as O-GlcNAcase imaging agents.

Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis

Caspases are responsible for the execution of the cell death program and are potentially suitable targets for the specific imaging of apoptosis in vivo. A series of N-1-substituted analogues of the small molecule nonpeptide caspase inhibitor (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (1), which may be useful for the development of caspase-targeted radioligands, were synthesized and their inhibition potencies were evaluated in vitro. Two of the most powerful techniques to introduce fluorine into organic compounds, viz, bromofluorination of olefins and fluorohydrin synthesis by ring-opening of epoxides, were used. Most of the target compounds are potent inhibitors of the two effector caspases-3 and -7. Furthermore, the 18F-radiolabeled model compound (S)-1-[4-(1-[18F]fluoro-2-hydroxyethyl)benzyl]-5-[1- (2-methoxymethyl-pyrrolidinyl) sulfonyl]isatin ([18F]37), a putative tracer for the noninvasive imaging of apoptosis by positron emission tomography (PET) was synthesized by nucleophilic epoxide ring-opening of its precursor 36. The radiochemistry utilized in the 18F-fluorination reverted to carrier-added [18F]Et3N·3HF, a new fluorine-18 source for radiolabeling.

CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.

Phenylpyridine derivatives

The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing such compoun

Indole derivatives

The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing such compounds and their m