321-84-6Relevant academic research and scientific papers
Nickel(0)-Catalyzed Hydroarylation of Styrenes and 1,3-Dienes with Organoboron Compounds
Xiao, Li-Jun,Cheng, Lei,Feng, Wei-Min,Li, Mao-Lin,Xie, Jian-Hua,Zhou, Qi-Lin
, p. 461 - 464 (2018)
A Ni-catalyzed hydroarylation of styrenes and 1,3-dienes with organoboron compounds has been developed. The reaction offers a highly selective approach to diarylalkanes and allylarenes under redox-neutral conditions. In this hydroarylation reaction, a new strategy that uses the proton of methanol to generate the active catalyst species Ni?H was developed. The Ni-catalyzed hydroarylation, combined with a Ir-catalyzed C?H borylation, affords a very efficient and straightforward access to a retinoic acid receptor agonist.
Iron-catalysed enantioconvergent Suzuki-Miyaura cross-coupling to afford enantioenriched 1,1-diarylalkanes
Tyrol, Chet C.,Yone, Nang S.,Gallin, Connor F.,Byers, Jeffery A.
, p. 14661 - 14664 (2020/12/02)
The first stereoconvergent Suzuki-Miyaura cross-coupling reaction was developed to afford enantioenriched 1,1-diarylalkanes. An iron-based complex containing a chiral cyanobis(oxazoline) ligand framework was best to obtain enantioenriched 1,1-diarylalkanes from cross-coupling reactions between unactivated aryl boronic esters and benzylic chlorides. Enhanced yields were obtained when 1,3,5-trimethoxybenzene was used as an additive, which is hypothesized to extend the lifetime of the iron-based catalyst. Exceptional enantioselectivities were obtained with challenging ortho-substituted benzylic chlorides. This journal is
Reductive cross-coupling of conjugated arylalkenes and aryl bromides with hydrosilanes by cooperative palladium/copper catalysis
Semba, Kazuhiko,Ariyama, Kenta,Zheng, Hong,Kameyama, Ryohei,Sakaki, Shigeyoshi,Nakao, Yoshiaki
supporting information, p. 6275 - 6279 (2016/05/24)
A method for the reductive cross-coupling of conjugated arylalkenes and aryl bromides with hydrosilanes by cooperative palladium/copper catalysis was developed, thus resulting in the highly regioselective formation of various 1,1-diarylalkanes, including a biologically active molecule. Under the applied reaction conditions, high levels of functional-group tolerance were observed, and the reductive cross-coupling of internal alkynes with aryl bromides afforded trisubstituted alkenes. Forming a Co-op: A method for the reductive cross-coupling of conjugated arylalkenes or internal alkynes and aryl bromides with hydrosilanes using cooperative palladium/copper catalysis was developed. The resulting 1,1-diarylalkanes and trisubstituted alkenes were isolated with high regio- and stereoselectivity. Under the applied reaction conditions, high levels of functional-group tolerance were observed.
