3211-19-6

Basic information

• Product Name: CIS-CYCLOBUTANE-1,2-DICARBONITRILE
• Synonyms: CIS-CYCLOBUTANE-1,2-DICARBONITRILE;CIS-1,2-CYCLOBUTANEDICARBONITRILE;(1R)-1β,2β-Cyclobutanedicarbonitrile;(1R,2S)-1,2-Cyclobutanedicarbonitrile;(1S)-1α,2α-Dicyanocyclobutane
• CAS NO: 3211-19-6
• Molecular Formula: C₆H₆N₂
• Molecular Weight: 106.13
• Product Categories: Aromatic Nitriles
• Mol File: 3211-19-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 145 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.08±0.1 g/cm3(Predicted)
• CAS DataBase Reference: CIS-CYCLOBUTANE-1,2-DICARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-CYCLOBUTANE-1,2-DICARBONITRILE(3211-19-6)
• EPA Substance Registry System: CIS-CYCLOBUTANE-1,2-DICARBONITRILE(3211-19-6)

Safety Data

• Hazardous Substances Data: 3211-19-6(Hazardous Substances Data)

Upstream product

• 65844-73-7 Trimethyl-1,1,4-butantricarboxylat 
• 22334-15-2 (+/-)-trans-cyclobutane-dicarboxylic acid-(1.2)-diamide 
• 107-13-1 acrylonitrile 

Downstream Products

• 1359850-59-1 C₁₉H₂₀F₂N₆O 
• 1359850-56-8 C₁₉H₂₀F₂N₆O 

Relevant articles and documents

Novel synthesis method of lobaplatin intermediate

The invention relates to the technical field of drug synthesis, in particular to a novel synthesis method of a loxetine intermediate, which is coupled through low-toxicity dimethyl malonate as a starting raw material. The synthesis of high purity trans -1, 2 - dicyanocyclobutane is carried out after the reaction of bromination, cyclization, hydrolysis, amidation and dehydration. In addition, the yield of the product is greatly improved, so that the cost is greatly reduced, the obtained trans -1 and 2 -dicyanocyclobutane are improved in purity, the subsequent use requirements are completely met, and the market competitiveness is greatly improved.