22334-15-2

Upstream product

• 7371-67-7 dimethyl trans-1,2-cyclobutane dicarboxylate 
• 1124-13-6 (+/-)-(1S,2S)-cyclobutane-1,2-dicarboxylic acid 
• 65844-73-7 Trimethyl-1,1,4-butantricarboxylat 

Downstream Products

• 3211-19-6 (1,2-trans)-cyclobutane-1,2-dicarbonitrile 

Relevant academic research and scientific papers

Novel synthesis method of lobaplatin intermediate

The invention relates to the technical field of drug synthesis, in particular to a novel synthesis method of a loxetine intermediate, which is coupled through low-toxicity dimethyl malonate as a starting raw material. The synthesis of high purity trans -1, 2 - dicyanocyclobutane is carried out after the reaction of bromination, cyclization, hydrolysis, amidation and dehydration. In addition, the yield of the product is greatly improved, so that the cost is greatly reduced, the obtained trans -1 and 2 -dicyanocyclobutane are improved in purity, the subsequent use requirements are completely met, and the market competitiveness is greatly improved.