321198-22-5

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure allows it to be a key component in the creation of medicinal compounds.
Used in Fragrance and Flavoring Industry:
METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE is utilized in the production of fragrances and flavorings, where its chemical properties can enhance or create specific scents and tastes in consumer products.
Used in Research and Development:
METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE is also used in research and development settings to explore new chemical products and understand its potential applications further, including possible uses in medicine and biotechnology.
Used in Medicine and Biotechnology:
Due to its unique chemical structure, METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE may have potential applications in medicine and biotechnology, although specific uses would depend on ongoing research and development in these fields.

Upstream product

• 123-75-1 pyrrolidine 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 

Downstream Products

• 887922-93-2 3-(pyrrolidin-1-ium-1-ylmethyl)benzoic acid chloride 
• 884507-42-0 3-(pyrrolidin-1′-ylmethyl)-benzaldehyde 
• 884507-41-9 3-((pyrrolidin-1-yl)methyl)benzoic acid 

Relevant academic research and scientific papers

New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure–activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3(trifluoromethyl)benzamide possessed good physicochemical properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50 (NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50 (K1 ) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved.

Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives

A new series of indanone and aurone derivatives have been synthesized and tested for in vitro AChE inhibitory activity by modified Ellman method. Most of them exhibit AChE inhibitory activities superior to rivastigmine. Further, the most potent compound 1g was selected to evaluate the effect on the acquisition and memory impairment by mice step-down passive avoidance test.

SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and 5 pharmaceutical compositions comprising them are disclosed; the compounds of the inv