321198-22-5

Basic information

• Product Name: METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE
• Synonyms: METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE;Methyl 3-(1-Pyrrolidylmethyl)benzoate;Methyl 3-(1-pyrrolidinylmethyl)benzoate;3-(1-pyrrolidinylmethyl)Benzoic acid methyl ester
• CAS NO: 321198-22-5
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.29
• Mol File: 321198-22-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE(321198-22-5)
• EPA Substance Registry System: METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE(321198-22-5)

Safety Data

• Hazardous Substances Data: 321198-22-5(Hazardous Substances Data)

Usage

General Description

METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE is a chemical compound with the molecular formula C16H19NO2. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. METHYL 3-((PYRROLIDIN-1-YL)METHYL)BENZOATE is an ester, with a benzoate group attached to the methyl group of a pyrrolidine derivative. It is often utilized in the production of drugs, fragrances, and flavorings, as well as in research and development of new chemical products. Additionally, it may have potential applications in the fields of medicine and biotechnology due to its unique chemical structure and properties.

Upstream product

• 123-75-1 pyrrolidine 
• 1129-28-8 3-methoxycarbonylbenzyl bromide 

Downstream Products

• 884507-41-9 3-((pyrrolidin-1-yl)methyl)benzoic acid 
• 884507-42-0 3-(pyrrolidin-1′-ylmethyl)-benzaldehyde 
• 887922-93-2 3-(pyrrolidin-1-ium-1-ylmethyl)benzoic acid chloride 

Relevant articles and documents

New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure–activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3(trifluoromethyl)benzamide possessed good physicochemical properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50 (NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50 (K1 ) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved.

SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

Substituted pyrrolo-pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and 5 pharmaceutical compositions comprising them are disclosed; the compounds of the inv