32137-27-2Relevant academic research and scientific papers
Enolization and ethylidene combined reaction method
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, (2022/04/03)
The invention discloses an enolation and ethylidenization combined reaction method. The method comprises the following steps: carrying out an enolation reaction of forming silyl enol ether from an alpha-alkyl ketone substrate and a silicon group at 35-45 DEG C in the presence of a mixed basic group and an organic solvent; performing ethylidene reaction on the obtained silyl enol ether product and an acetaldehyde reagent at-35 to 15 DEG C in the presence of boron trifluoride and an organic solvent to obtain an ethylidene product; the mixed basic groups are two or more than two of triethylamine, 2, 2-methylmorpholine and tert-butylamine; the ratio of the amount of substance of the mixed basic group to the amount of substance of the alpha-alkyl ketone substrate is (1-3): 1. The method not only protects and stabilizes the intermediate enolate of the reaction, but also catalyzes the reaction process of enolation and lewis acid, and is good in reaction selectivity, so that the enolation reaction product can be stably subjected to regiospecific ethylidene reaction.
Preparation of α,β-unsaturated carbonyl compounds
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, (2008/06/13)
A process for the preparation of α,β-unsaturated carbonyl compounds of the formula I STR1 where R1 is hydrogen, C1 -C10 -alkyl, C1 -C10 -alkoxy or aryloxy, R2 is aryl which is unsubstituted or substituted by C1 -C4 -alkyl, C1 -C4 -alkoxy, trifluoromethyl and/or halogen and R3 is tetrahydrofuranyl or aryl which is substituted by C1 -C4 -alkyl, C1 -C4 -alkoxy, trifluoromethyl and/or halogen, which comprises reacting 3-amino-2-propen-1-ones of the formula II STR2 where R1 and R2 have the abovementioned meanings, and R4 and R5 are, independently of one another, hydrogen, C1 -C10 -alkyl or aryl, with a magnesium halide of the formula III where Y is halogen, at from -20° to 100° C., and novel α,β-unsaturated carbonyl compounds and novel 3-amino-2-propen-1-ones are described.
