321394-48-3

Basic information

• Product Name: 4-ethyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
• Synonyms: 4-ethyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine
• CAS NO: 321394-48-3
• Molecular Weight: 311.424
• Mol File: 321394-48-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-ethyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine(321394-48-3)
• EPA Substance Registry System: 4-ethyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine(321394-48-3)

Safety Data

• Hazardous Substances Data: 321394-48-3(Hazardous Substances Data)

Upstream product

• 155955-78-5 3,4-dimethoxyphenylacetic acid N,O-dimethylhydroxyamide 
• 884-06-0 1-(3',4'-dimethoxyphenyl)-2-butanone 
• 321394-42-7 2-[1-(3,4-dimethoxy-benzyl)-propylamino]-1-phenyl-ethanol 

Relevant articles and documents

Two general routes to 1,4-disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines.

[structure] Two general routes to 1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepines are described. Both routes utilize an appropriately functionalized phenethylamino alcohol as the penultimate intermediate: the first route makes use of the reductive amination of a benzyl alkyl ketone with alpha-(aminomethyl)benzyl alcohol, while the second route utilizes the addition of a Grignard reagent to the oxazolidine derived from a substitued phenylacetaldehyde and alpha-(methylaminomethyl)benzyl alcohol. In all cases studied, the cis-1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepine was obtained as the major product.