884-06-0

Usage

Chemical Properties

Yellow Oil

Uses

1-(3,4-Dimethoxyphenyl)-2-butanone (cas# 884-06-0) is a compound useful in organic synthesis.

InChI:InChI=1/C12H16O3/c1-4-10(13)7-9-5-6-11(14-2)12(8-9)15-3/h5-6,8H,4,7H2,1-3H3

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 155955-78-5 3,4-dimethoxyphenylacetic acid N,O-dimethylhydroxyamide 
• 100613-28-3 methyl 4-(3,4-dimethoxyphenyl)-3-oxobutanoate 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 78765-14-7 t-butyl 2-ethyl-2,3-epoxy-3-(3',4'-dimethoxyphenyl)-propanoate 

Downstream Products

• 78765-15-8 4-(3',4'-dimethoxyphenyl)-3-hexnone 
• 321394-42-7 2-[1-(3,4-dimethoxy-benzyl)-propylamino]-1-phenyl-ethanol 
• 321394-48-3 4-ethyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 84675-75-2 3-(p-methoxyphenyl)-4-(3',4'-dimethoxyphenyl)-3-hexene 
• 78765-16-9 3-(p-methoxyphenyl)-4-(3',4'-dimethoxyphenyl)-3-hexanol 
• 71113-07-0 3'-hydroxydiethylstilbestrol 
• 78765-18-1 C₂₁H₂₆O₃ 
• 5459-28-9 4-((1RS,2SR)-1-ethyl-2-phenyl-butyl)-pyrocatechol 
• 112744-08-8 (+/-)-erythro-3-(3,4-dimethoxy-phenyl)-4-phenyl-hexane 
• 439-39-4 4-[(1RS,2SR)-1-ethyl-2-(4-fluoro-phenyl)-butyl]-pyrocatechol 
• 482-57-5 (+/-)-erythro-3-(3,4-dimethoxy-phenyl)-4-(4-fluoro-phenyl)-hexane 
• 110249-50-8 4-(3,4-dimethoxy-phenyl)-3-phenyl-hexan-3-ol 
• 468-91-7 4-(3,4-dimethoxy-phenyl)-3-(4-fluoro-phenyl)-hexan-3-ol 
• 17249-61-5 (5,6-dimethoxybenzofuran-2-yl)ethan-2-one 

Relevant academic research and scientific papers

Synthesis of Benzo[ b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis

One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogues, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.

Enantioselective reduction of β-keto acids with engineered streptomyces coelicolor

Compelling evidence for the intermediacy of the free β-keto acid 1, rather than the corresponding enzyme-bound thiolate as previously proposed, in the biosynthesis of the antibiotic actinorhodin (2) was obtained from studies of the enantioselective reduction of a range of β-keto acids by the engineered strain of S. coelicolor CH999/pIJ5675. This excellent whole-cell biotransformation system gave the desired S β-hydroxy acids with >95% ee.

Two general routes to 1,4-disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines.

[structure] Two general routes to 1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepines are described. Both routes utilize an appropriately functionalized phenethylamino alcohol as the penultimate intermediate: the first route makes use of the reductive amination of a benzyl alkyl ketone with alpha-(aminomethyl)benzyl alcohol, while the second route utilizes the addition of a Grignard reagent to the oxazolidine derived from a substitued phenylacetaldehyde and alpha-(methylaminomethyl)benzyl alcohol. In all cases studied, the cis-1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepine was obtained as the major product.

SYNTHESIS OF METABOLIC INTERMEDIATES OF DIETHYLSTILBESTROL

This report details the synthesis of 1) 3,4,4'-trihydroxy-α,α'-diethyl-trans-stilbene; 2) 3,4-bis-(p-hydroxyphenyl)-trans-3-hexenol; 3) 3,4-bis-(p-hydroxyphenyl)-2,4-cis,cis-hexadienol; 4) 3,4-bis-(3'-methoxy-4'-hydroxyphenyl)-trans-3-hexene; 5) 3,4-bis-(3',4'-dimethoxyphenyl)-trans-3-hexene.These compounds are suspected metabolites of diethylstilbestrol.