32140-71-9Relevant academic research and scientific papers
Design, Synthesis and In Vivo Anxiolytic Activity of Novel Flavonoids
Sabale,Potey
, p. 908 - 914 (2021/12/08)
Worldwide millions of peoples are suffering from psychological disorders of which anxiety is one of the major and common problems. Knowing statistical reports of anxiety, the present research focused on design of new flavonoid derivatives through molecular docking by using Schr?dinger (Maestro 10.5 v), the well-known computational software on the basis of ligand – protein interaction. The most effective flavonoid derivatives with potent Glide score (IC50) values – compounds 3a (–6.824), 3b (–7.215), 3e (–6.239), 3f (-6.679), and 3j (–7.123) – were selected for the synthesis under microwave irradiation in two-step reaction involving the Claisen-Schmidth condensation to form chalcones and oxidative cyclization to form flavonoids. Then, in vivo anxiolytic activity of synthesized derivatives was studied in adult Swiss albino mice using the elevated plus-maze test model. Diazepam (2 mg/kg, IP) was used as standard drug. Compound 3b exhibited most significant anxiolytic activity against GABAA receptor, but other compounds also showed significant anxiolytic effect in mice at 100 and 200 mg/kg doses when compared to Diazepam.
Microwave assisted synthesis of 4,6-dichloro-2,8-diaryl-2H, 8H-pyrano [3,2-G] chromenes and their antimicrobial activity
Sarasija,Shravani,Ashok
, p. 349 - 352 (2019/01/21)
A series of 4,6-dichloro-2,8-diaryl-2H, 8H-pyrano [3,2-g] chromenes have been synthesized by the reaction of various 4,6-dicinnamoyl resorcinols with Vilsmeier reagent under microwave irradiation and conventional heating. The structures of newly synthesiz
