321432-57-9Relevant academic research and scientific papers
Synthesis and antimicrobial evaluation of novel pyrazolopyrimidines incorporated with mono- And diphenylsulfonyl groups
Alsaedi, Amani M.R.,Farghaly, Thoraya A.,Shaaban, Mohamed R.
, (2019)
A novel series of pyrazolo[1,5-a]pyrimidine ring systems containing phenylsulfonyl moiety have been synthesized via the reaction of 2-(phenylsulfonyl)-1-(4-(phenylsulfonyl) phenyl)ethan-1-one, 2-benzenesulfonyl-1-(4-benzenesulfonyl-phenyl)-3-dimethylamino-propenone and 3-(dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one each with various substituted aminoazopyrazole derivatives in one pot reaction strategy. The proposed structure as well as the mechanism of their reactions were discussed and proved with all possible spectral data. The results of antimicrobial activities of the new sulfone derivatives revealed that several derivatives showed activity exceeding the activity of reference drug. Contrary to expectations, we found that derivatives containing one sulfone group are more effective against all bacteria and fungi used than those contain two sulfone groups.
Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors
Bingham, Alistair H.,Davenport, Richard J.,Fosbeary, Richard,Gowers, Lewis,Knight, Roland L.,Lowe, Christopher,Owen, David A.,Parry, David M.,Pitt, Will R.
scheme or table, p. 3622 - 3627 (2009/04/06)
The synthesis and structure-activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.
